TAILIEUCHUNG - báo cáo khoa học: " A role for neurotransmission and neurodevelopment in attention‑deficit/hyperactivity disorder"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: A role for neurotransmission and neurodevelopment in attention‑deficit/hyperactivity disorder | Genome Medicine Minireview A role for neurotransmission and neurodevelopment in attention-deficit hyperactivity disorder Tatiana Roman Luis A Rohdet and Mara H Hutz Addresses Departamento de Genética Universidade Federal do Rio Grande do Sul Av. Bento Gongalves 9500 - Prédio 43323 Sala 115 Caixa postal 15053 CEP 91501-970 Porto Alegre RS Brasil. 1ADHD Outpatient Program Servigo de Psiquiatria da Infancia e Adolescência Hospital de Clinicas de Porto Alegre Universidade Federal do Rio Grande do Sul Instituto Nacional de Psiquiatria do Desenvolvimento Rua Ramiro Barcelos 2350 CEP 90035-003 Porto Alegre RS Brazil. Correspondence Mara H Hutz. Email Abstract Attention-deficit hyperactivity disorder ADHD has a moderate to high genetic component probably due to many genes with small effects. Several susceptibility genes have been suggested on the basis of hypotheses that catecholaminergic pathways in the brain are responsible for ADHD. However many negative association findings have been reported indicating a limited success for investigations using this approach. The results from genome-wide association studies have suggested that genes related to general brain functions rather than specific aspects of the disorder may contribute to its development. Plausible biological hypotheses linked to neurotransmission and neurodevelopment in general and common to different psychiatric conditions need to be considered when defining candidate genes for ADHD association studies. Introduction Although the etiology of attention-deficit hyperactivity disorder ADHD is not completely understood it is well known that the disorder has a moderate to high genetic component with an estimated heritability of 76 1 . The mode of transmission is likely to be due to many susceptibility genes with small effects. Moreover recent research findings have highlighted the relevance of gene-gene and geneenvironment interactions in explaining the heterogeneous ADHD phenotype 2-4 . Several

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