TAILIEUCHUNG - Báo cáo khoa học: "Pro/con debate: Antifungal prophylaxis is important to prevent fungal infection in patients with acute necrotizing pancreatitis receiving broad-spectrum antibiotics"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Pro/con debate: Antifungal prophylaxis is important to prevent fungal infection in patients with acute necrotizing pancreatitis receiving broad-spectrum antibiotics. | Available online http content 10 5 229 Review Pro con debate Antifungal prophylaxis is important to prevent fungal infection in patients with acute necrotizing pancreatitis receiving broad-spectrum antibiotics Philippe Eggimann1 Saurabh Jamdar2 and Ajith K Siriwardena2 1 Department of Intensive Care Medicine and Burn Unit Interdisciplinary Department for Support and Technics Centre Hospitalier Universitaire Vaudois CHUV Lausanne Switzerland 2Hepatobiliary Surgery Unit Department of Surgery Manchester Royal Infirmary Manchester UK Corresponding author A Siriwardena Published 7 September 2006 This article is online at http content 10 5 229 2006 BioMed Central Ltd Critical Care 2006 10 229 doi cc5025 Abstract When critically ill patients with pancreatitis develop infection of the pancreas the ongoing management of such patients becomes difficult. Sufficient evidence supports the use of broad-spectrum antibiotic prophylaxis to prevent the development of bacterial infection. Since fungal infection is also a relatively common complication of severe pancreatitis - particularly when broadspectrum antibiotics are used - it seems logical that fungal prophylaxis may be an important component of management. In this issue of Critical Care two expert groups debate the merits of antifungal prophylaxis in patients with acute necrotizing pancreatitis who are receiving antibiotics. Pro Antifungal prophylaxis should be parallel to Philippe Eggimann Acute pancreatitis is severe in only 20 of patients with the disease but despite continuous advances in supportive treatments the prognosis for these patients has not improved over the past decades. Necrosis of the pancreatic tissue develops early in 25 to 40 of patients and for those who survive to an eventual initial multiple organ failure mortality rates up to 60 have been linked to the high proportion of superinfections 1 . Gram-negative bacteria and fungi progressively .

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