TAILIEUCHUNG - Báo cáo y học: "valuation of a recombinant human gelatin as a substitute for a hydrolyzed porcine gelatin in a refrigerator-stable Oka/Merck live varicella vaccine."

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Evaluation of a recombinant human gelatin as a substitute for a hydrolyzed porcine gelatin in a refrigerator-stable Oka/Merck live varicella vaccine. | Journal of Immune Based Therapies and Vaccines BioMed Central Open Access Evaluation of a recombinant human gelatin as a substitute for a hydrolyzed porcine gelatin in a refrigerator-stable Oka Merck live varicella vaccine Vladimir Liska 1 Stacey A Bigert2 Philip S Bennett3 David Olsen4 Robert Chang4 and Carl J Burke2 Address 1Vaccine Clinical Research Merck Research Laboratories . Box 1000 UG3CD28 North Wales PA 19454 USA 2Biologics and Vaccines Merck Research Laboratories West Point PA 19486 USA 3NonClinical Statistics Merck Research Laboratories West Point PA 19486 USA and 4FibroGen Inc. South San Francisco CA 94080 USA Email Vladimir Liska - vladimir_liska@ Stacey A Bigert - stacey_bigert@ Philip S Bennett - philip_bennett@ David Olsen - DOlsen@ Robert Chang - RChang@ Carl J Burke - carl_burke@ Corresponding author Published 23 February 2007 Received 15 December 2006 __ -r _ .J1Z_. .AAA-7 J. .IA I IOZJU7Z orior Accepted 23 February 2007 Journal of Immune Based Therapies and Vaccines 2007 5 4 doi l476-85l8-5-4 This article is available from http content 5 l 4 2007 Liska et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ Background The labile nature of live attenuated varicella-zoster virus Oka Merck requires robust stabilization during virus bulk preparation and vaccine manufacturing in order to preserve potency through storage and administration. One stabilizing ingredient used in a varicella-zoster virus VZV vaccine is hydrolyzed porcine gelatin which represents the major protein peptide-based excipient in the

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