TAILIEUCHUNG - Báo cáo y học: " Six host range variants of the xenotropic/polytropic gammaretroviruses define determinants for entry in the XPR1 cell surface receptor"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Retrovirology cung cấp cho các bạn kiến thức về ngành y đề tài: " Six host range variants of the xenotropic/polytropic gammaretroviruses define determinants for entry in the XPR1 cell surface receptor. | Retrovirology BioMed Central Open Access Six host range variants of the xenotropic polytropic gammaretroviruses define determinants for entry in the XPR1 cell surface receptor Yuhe Yan Qingping Liu and Christine A Kozak Address Laboratory of Molecular Microbiology National Institute of Allergy and Infectious Diseases Bethesda MD 20892-0460 USA Email Yuhe Yan - yyan@ Qingping Liu - liuqing@ Christine A Kozak - ckozak@ Corresponding author Published 7 October 2009 Received 21 August 2009 Retrovirology 2009 6 87 doi 1742-4690-6-87 Accepted 7 October 2009 This article is available from http content 6 1 87 2009 Yan et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The evolutionary interactions between retroviruses and their receptors result in adaptive selection of restriction variants that can allow natural populations to evade retrovirus infection. The mouse xenotropic polytropic X PMV gammaretroviruses rely on the XPR1 cell surface receptor for entry into host cells and polymorphic variants of this receptor have been identified in different rodent species. Results We screened a panel of X PMVs for infectivity on rodent cells carrying 6 different XPR1 receptor variants. The X PMVs included 5 well-characterized laboratory and wild mouse virus isolates as well as a novel cytopathic XMV-related virus termed Cz524 isolated from an Eastern European wild mouse-derived strain and XMRV a xenotropic-like virus isolated from human prostate cancer. The 7 viruses define 6 distinct tropisms. Cz524 and another wild mouse isolate CasE 1 have unique species tropisms. Among the PMVs one Friend isolate is restricted by rat cells. Among the XMVs two .

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