TAILIEUCHUNG - Báo cáo hóa học: " Postcardiac arrest syndrome: from immediate resuscitation to long-term outcome"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí hóa hoc quốc tế đề tài : Postcardiac arrest syndrome: from immediate resuscitation to long-term outcome | Mongardon et al. Annals of Intensive Care 2011 1 45 http content 1 1 45 Ù Annals of Intensive Care a SpringerOpen Journal REVIEW Open Access Postcardiac arrest syndrome from immediate resuscitation to long-term outcome 3 1 Nicolas Mongardon Florence Dumas Sylvie Ricome David Grimaldi Tarik Hissem Frédéric Pène and Alain Cariou1 2 3 Abstract The prognosis for postcardiac arrest patients remains very bleak not only because of anoxic-ischemic neurological damage but also because of the postcardiac arrest syndrome a phenomenon often severe enough to cause death before any neurological evaluation. This syndrome includes all clinical and biological manifestations related to the phenomenon of global ischemia-reperfusion triggered by cardiac arrest and return of spontaneous circulation. The main component of the postcardiac arrest syndrome is an early but severe cardiocirculatory dysfunction that may lead to multiple organ failure and death. Cardiovascular support relies on conventional medical and mechanical treatment of circulatory failure. Hemodynamic stabilization is a major objective to limit secondary brain insult. When the cause of cardiac arrest is related to myocardial infarction percutaneous coronary revascularization is associated with improved prognosis early angiographic exploration should then be discussed when there is no obvious extracardiac cause. Therapeutic hypothermia is now the cornerstone of postanoxic cerebral protection. Its widespread use is clearly recommended with a favorable risk-benefit ratio in selected population. Neuroprotection also is based on the prevention of secondary cerebral damages pending the results of ongoing therapeutic evaluations regarding the potential efficiency of new therapeutic drugs. Introduction Sudden death remains a major public health issue despite improvements in prehospital management and standardization of advanced life support through wide diffusion of international .

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