TAILIEUCHUNG - Báo cáo y học: "Complex systems and the technology of variability analysis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care cung cấp cho các bạn kiến thức về ngành y đề tài: Complex systems and the technology of variability analysis. | Available online http content 8 6 R367 Research Complex systems and the technology of variability analysis Andrew JE Seely1 and Peter T Macklem2 Open Access Assistant Professor Thoracic Surgery and Critical Care Medicine University of Ottawa Ottawa Ontario Canada 2Professor Emeritus Respiratory Medicine McGill University Montreal Quebec Canada Corresponding author Andrew JE Seely aseely@ Received 21 May 2004 Revisions requested 7 July 2004 Revisions received 5 August 2004 Accepted 9 August 2004 Published 22 September 2004 Critical Care 2004 8 R367-R384 DOI cc2948 This article is online at http content 8 6 R367 2004 Seely et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License thhp licences by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Characteristic patterns of variation over time namely rhythms represent a defining feature of complex systems one that is synonymous with life. Despite the intrinsic dynamic interdependent and nonlinear relationships of their parts complex biological systems exhibit robust systemic stability. Applied to critical care it is the systemic properties of the host response to a physiological insult that manifest as health or illness and determine outcome in our patients. Variability analysis provides a novel technology with which to evaluate the overall properties of a complex system. This review highlights the means by which we scientifically measure variation including analyses of overall variation time domain analysis frequency distribution spectral power frequency contribution spectral analysis scale invariant fractal behaviour detrended fluctuation and power law analysis and regularity approximate and multiscale entropy . Each technique is presented with a definition interpretation clinical .

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