TAILIEUCHUNG - Báo cáo khoa học: "Endogenous angiotensin II in the regulation of hypoxic pulmonary vasoconstriction in anaesthetized dog"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài:Endogenous angiotensin II in the regulation of hypoxic pulmonary vasoconstriction in anaesthetized dogs. | Available online http content 8 4 R163 Research Endogenous angiotensin II in the regulation of hypoxic pulmonary vasoconstriction in anaesthetized dogs Ives Hubloue1 Benoĩt Rondelet2 Franpois Kerbaul2 Dominique Biarent2 Guiti Malekzadeh Milani2 Michel Staroukine3 Pierre Bergmann3 Robert Naeije2 and Marc Leeman2 Open Access Department of Intensive Care Medicine Akademisch Ziekenhuis VUB and Laboratory of Physiology Faculty of Medicine Erasme Campus of the Free University of Brussels Brussels Belgium 2Laboratory of Physiology Faculty of Medicine Erasme Campus of the Free University of Brussels Brussels Belgium 3Laboratory of Radioimmunology and Experimental Medicine Brugmann Hospital Brussels Belgium Corresponding author Ives Hubloue Received 28 November 2003 Revisions requested 22 January 2004 Revisions received 26 March 2004 Accepted 7 April 2004 Published 14 May 2004 Critical Care 2004 8 R163-R171 DOI cc2860 This article is online at http content 8 4 R163 2004 Hubloue et al. licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Introduction The role played by several vasoactive mediators that are synthesized and released by the pulmonary vascular endothelium in the regulation of hypoxic pulmonary vasoconstriction HPV remains unclear. As a potent vasoconstrictor angiotensin II could be involved. We tested the hypothesis that angiotensin-converting enzyme inhibition by enalaprilat and type 1 angiotensin II receptor blockade by candesartan would inhibit HPV. Methods HPV was evaluated in anaesthetized dogs with an intact pulmonary circulation by examining the increase in the Ppa-Ppao gradient mean pulmonary artery pressure minus occluded pulmonary artery pressure that occurred in response to hypoxia inspiratory oxygen fraction of .

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