TAILIEUCHUNG - Báo cáo khoa học: "N-acetylcysteine decreases lactate signal intensities in liver tissue and improves liver function in septic shock patients, as shown"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: N-acetylcysteine decreases lactate signal intensities in liver tissue and improves liver function in septic shock patients, as shown . | Critical Care April 2004 Vol 8 No 2 Vargas Hein et al. Research Open Access N-acetylcysteine decreases lactate signal intensities in liver tissue and improves liver function in septic shock patients as shown by magnetic resonance spectroscopy extended case report Ortrud Vargas Hein1 Renate Ohring2 Andreas Schilling2 Michael Oellerich3 Victor W Armstrong3 Wolfgang J Kox1 and Claudia Spies1 1 Department of Anesthesiology and Intensive Care Medicine Charité Campus Mitte Humboldt University Berlin Germany 2Department of Neurology Benjamin Franklin Medical Center Free University Berlin Germany 3Department of Clinical Chemistry Georg-August University Gottingen Germany Correspondence Prof. Dr med. Claudia Spies Received 19 November 2003 Accepted 17 December 2003 Published 22 January 2004 Critical Care 2004 8 R66-R71 DOI cc2426 This article is online at http content 8 2 R66 2004 Vargas Hein et al. licensee BioMed Central Ltd Print ISSN 1364-8535 Online ISSN 1466-609X . This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Background M-acetylcysteine NAC has been shown to improve splanchnic blood flow in experimental studies. This report evaluates the effects of NAC on liver perfusion and lactate signal intensities in the liver tissue of septic shock patients using proton magnetic resonance imaging and spectroscopy. Furthermore the monoethylglycinexylidide MEGX test was used to investigate hepatic function. Methods Five septic shock patients received 150 mg kg body weight NAC as an intravenous bolus injection over 15 min. Lidocaine was injected both prior to and following NAC administration in order to determine MEGX formation. Measurements hemodynamics oxygen transport-related variables blood samples for lactate liver-related markers were performed 1 hour before and 1 hour .

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