TAILIEUCHUNG - Báo cáo y học: " Anti-Fas mAb-induced apoptosis and cytolysis of airway tissue eosinophils aggravates rather than resolves established inflammation"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Anti-Fas mAb-induced apoptosis and cytolysis of airway tissue eosinophils aggravates rather than resolves established inflammation. | Respiratory Research BioMed Central Research Open Access Anti-Fas mAb-induced apoptosis and cytolysis of airway tissue eosinophils aggravates rather than resolves established inflammation Lena Uller 1 Kristina Rydell-Tormanen1 Carl GA Persson2 and Jonas S Erjefalt1 Address 1Dept. Experimental Medical Science Lund University BMC F10 221 84 Lund Sweden and 2Dept. Clinical Pharmacology Lund University Hospital Lund Sweden Email Lena Uller - Kristina Rydell-Tormanen - Carl GA Persson - Jonas S Erjefalt - Corresponding author Published 08 August 2005 Received 30 June 2005 Respiratory Research 2005 6 90 doi 1465-9921 -6-90 Accepted 08 August 2005 This article is available from http content 6 1 90 2005 Uller et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Fas receptor-mediated eosinophil apoptosis is currently forwarded as a mechanism resolving asthma-like inflammation. This view is based on observations in vitro and in airway lumen with unknown translatability to airway tissues in vivo. In fact apoptotic eosinophils have not been detected in human diseased airway tissues whereas cytolytic eosinophils abound and constitute a major mode of degranulation of these cells. Also Fas receptor stimulation may bypass the apoptotic pathway and directly evoke cytolysis of non-apoptotic cells. We thus hypothesized that effects of anti-Fas mAb in vivo may include both apoptosis and cytolysis of eosinophils and hence that established eosinophilic inflammation may not resolve by this treatment. Methods Weeklong daily allergen challenges of sensitized mice were followed by airway .

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