TAILIEUCHUNG - Báo cáo y học: "Anaphylatoxin C3a receptors in asthma"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:Anaphylatoxin C3a receptors in asthma. | Respiratory Research BioMed Central Review Anaphylatoxin C3a receptors in asthma Hydar Ali 1 and Reynold A Panettieri Jr2 Open Access Address Department of Pathology School of Dental Medicine University of Pennsylvania 240 South 40th Street Philadelphia PA 19104 USA and 2Pulmonary Allergy and Critical Care Division Department of Medicine University of Pennsylvania BRBII III 421 Curie Boulevard Philadelphia pA 19104 USA Email Hydar Ali - ali@ Reynold A Panettieri - rap@ Corresponding author Published 21 February 2005 Received 10 February 2005 Respiratory Research 2005 6 19 doi l465-992l-6-l9 Accepted 21 February 2005 This article is available from http content 6 l l9 2005 Ali and Panettieri licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract The complement system forms the central core of innate immunity but also mediates a variety of inflammatory responses. Anaphylatoxin C3a which is generated as a byproduct of complement activation has long been known to activate mast cells basophils and eosinophils and to cause smooth muscle contraction. However the role of C3a in the pathogenesis of allergic asthma remains unclear. In this review we examine the role of C3a in promoting asthma. Following allergen challenge C3a is generated in the lung of subjects with asthma but not healthy subjects. Furthermore deficiency in C3a generation or in G protein coupled receptor for C3a abrogates allergen-induced responses in murine models of pulmonary inflammation and airway hyperresponsiveness. In addition inhibition of complement activation or administration of small molecule inhibitors of C3a receptor after sensitization but before allergen challenge inhibits .

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