TAILIEUCHUNG - Báo cáo y học: "Stimulation of allergen-loaded macrophages by TLR9-ligand potentiates IL-10-mediated suppression of allergic airway inflammation in mice"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:Stimulation of allergen-loaded macrophages by TLR9-ligand potentiates IL-10-mediated suppression of allergic airway inflammation in mice. | Respiratory Research BioMed Central Research Open Access Stimulation of allergen-loaded macrophages by TLR9-ligand potentiates IL-10-mediated suppression of allergic airway inflammation in mice Joost LM Vissers1 Betty CAM van Esch1 Prescilla V Jeurink1 Gerard A Hofman1 and Antoon JM van Oosterhout 1 2 Address Department of Pharmacology and Pathophysiology Faculty of Pharmaceutical Sciences Utrecht University Sorbonnelaan 16 3584 CA Utrecht The Netherlands and 2Lab. Allergology Pulmonary Diseases Dept. Pathology Lab. Medicine Groningen University Hospital Hanzeplein 1 PO Box 9700 RB Groningen The Netherlands Email Joost LM Vissers - Betty CAM van Esch - Prescilla V Jeurink - Gerard A Hofman - Antoon JM van Oosterhout - Corresponding author Published II November 2004 Received 20 July 2004 Accepted 1 1 November 2004 Respiratory Research 2004 5 21 doi 1465-9921 -5-21 This article is available from http content 5 1 21 2004 Vissers et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Previously we demonstrated that OVA-loaded macrophages OVA-MỘ partially suppress OVA-induced airway manifestations of asthma in BALB c mice. In vitro studies showed that OVA-MỘ start to produce IL-10 upon interaction with allergen-specific T cells which might mediate their immunosuppressive effects. Herein we examined whether IL-10 is essential for the immunosuppressive effects of OVA-MỘ in vivo and whether ex vivo stimulation of the IL-10 production by OVA-MỘ could enhance these effects. Methods Peritoneal MỘ were loaded with OVA and stimulated with .

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