TAILIEUCHUNG - Báo cáo y học: "In-vivo evaluation of simultaneous administration of incompatible drugs in a central venous catheter with a decreased port to port distance"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: In-vivo evaluation of simultaneous administration of incompatible drugs in a central venous catheter with a decreased port to port distance. | Please note This paper has not been approved for publication at present Research paper 51 In-vivo evaluation of simultaneous administration of incompatible drugs in a central venous catheter with a decreased port to port distance Gerardo Reyes Gurpreet S Mander Tarek S Husayni Rabi F Sulayman and David G Jaimovich Background Multilumen catheters are commonly used in critically ill children. Their use however is associated with significant morbidity. We studied the simultaneous administration of incompatible drugs using a new triple-lumen catheter with decreased length and port to port distances. Methods Ten domestic swine 10-20 kg in weight were divided into two groups of five. Total parenteral nutrition was administered through the distal port and phenytoin was administered as a bolus and as an infusion in each group. Samples were taken from two sites during the bolus and at 1 5 and 15 min during phenytoin infusion. Histograms were generated for particle size and concentration. Samples were also examined under the microscope for particles. Results Histograms of particle size did not show any alteration of the histogram that would suggest particle size 2 ự m in diameter in the study or control samples. No particles were identified by phase microscope light microscope or Wright stain smear. Conclusions The use of a triple-lumen catheter with a distance of cm between the proximal port and the medial port and cm between the medial port and the distal port for the in vivo simultaneous administration of incompatible solutions does not result in precipitates large enough to cause adverse clinical effects. Addresses Hope Children s Hospital Division of Critical Care Oak Lawn Illinois USA The University of Illinois at Chicago School of Medicine Chicago Illinois USA. Correspondence Gerardo Reyes MD FCCM Hope Children s Hospital Director Critical Care Training 4440 West 95 th Street Oak Lawn IL 60453-2699 USA. Tel 708 346 5685 fax 708 346 4714 e mail .

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