TAILIEUCHUNG - Báo cáo y học: "ntensive care management of organophosphate insecticide poisoning"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: ntensive care management of organophosphate insecticide poisoning. | Available online http content 5 4 211 Research article Intensive care management of organophosphate insecticide poisoning Murat Sungur and Muhammed Guven Department of Internal Medicine School of Medicine Erciyes Universitesi Tip Fakultesi Kayseri Turkey Correspondence Murat Sungur msungur1@ Received 11 September 2000 Revisions requested 7 November 2000 Revisions received 2 February 2001 Accepted 15 April 2001 Published 31 May 2001 Critical Care 2001 5 211-215 2001 Sungur and Guven licensee BioMed Central Ltd Print ISSN 1364-8535 Online ISSN 1466-609X Abstract Introduction Organophosphate OP insecticides inhibit both acetylcholinesterase and pseudocholinesterase activities. The clinical course of OP poisoning may be quite severe and may need intensive care management. We report our experience with the intensive care management of serious OP insecticide poisonings. Methods A retrospective study was performed on the patients with OP poisoning followed at our medical intensive care unit. Forty-seven patients were included. Diagnosis was performed from the history taken either from the patient or from the patient s relatives regarding the agent involved in the exposure. Intravenous atropine and pralidoxime was administered as soon as possible. Pralidoxime could not be given to 16 patients 2 patients did not receive pralidoxime because they were late admissions and 14 did not receive pralidoxime because the Ministry of Health office was out of stock. Data are presented as mean standard deviation. Results There were 25 female and 22 male patients. Thirty-two 68 were suicide attempts and 15 32 were accidental exposure patients. The mortality rates for the patients who did and did not receive pralidoxime were 32 and respectively and were not statistically different. Ten patients required mechanical ventilation. The mortality rate for the patients who required mechanical ventilation was 50 but the rate was for those patients who were not

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