TAILIEUCHUNG - Báo cáo y học: "Editorial comment"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Editorial comment. | Editorial comment 17 Editorial comment Waheedullah Karzai and Konrad Reinhart Address Department of Anesthesiology and Intensive Care Medicine University Hospital Friedrich-Schiller-University Jena 07740 Jena Germany. Correspondence Prof. Dr. med. Konrad Reinhart Department of Anesthesiology and Intensive Care Medicine University Hospital Friedrich-Schiller-University Jena 07740 Jena Germany. Tel 49 3641 933041 fax 49 3641 933256 e-mail reinhart@ Received 13 May 1998 Accepted 11 February 1999 Published 15 March 1999 Crit Care 1999 3 17-18 The original version of this paper is the electronic version which can be seen on the Internet http . The electronic version may contain additional information to that appearing in the paper version. Current Science Ltd ISSN 1364-8535 In this issue of the journal Steinwald et al 1 extend limited clinical studies and report an animal experiment showing that calcitonin precursors predominantly procalcitonin are elevated in proportion to the severity of bacterial sepsis. They conclude that procalcitonin the major calcitonin precursor is a good indicator of the activity and severity of the inflammatory response and may be used for monitoring bacterial infections. In recent years a variety of laboratory and immunologic parameters have been proposed as possible indicators of severe inflammatory response to infections. One such parameter is procalcitonin which has emerged as a possible marker of severe generalized infections 2 . The exact role of procalcitonin during infection is unclear. The elevated amount found during sepsis does not lead to increased levels of calcitonin and there is as yet no evidence that it may be involved in calcium metabolism. Also its exact site of production during sepsis is unclear however recent research suggests that the monocytes may be one possible source during sepsis. Despite the unknown and potentially very important pathophysiology of procalcitonin during sepsis much .

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