TAILIEUCHUNG - Báo cáo y học: "Fluctuations of inspired concentrations of nitric oxide and nitrogen dioxide during mechanical ventilation"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Fluctuations of inspired concentrations of nitric oxide and nitrogen dioxide during mechanical ventilation. | Research paper 1 Fluctuations of inspired concentrations of nitric oxide and nitrogen dioxide during mechanical ventilation Ralf Kuhlen Thilo Busch Martin Max Matthias Reyle-Hahn Konrad J Falke and Rolf Rossaint Background Nitric oxide NO is a very reactive agent with potentially toxic oxidation products such as nitrogen dioxide NO2 . Therefore during NO inhalation a constant inspired concentration and accurate measurement of NO and NO2 concentrations are essential. The objective of this study was to test the NO concentrations at various positions along the inspiratory limb of the breathing circuit using a recently developed system to administer NO in phase with inspiratory flow during mechanical ventilation Servo 300 NO-A Siemens Sweden . Furthermore we tested whether an active heating system would interfere with inspired NO concentrations. Results A sharp decline in the NO concentration was found between the respirator s inspiratory outlet and more distal points along the inspiratory limb of the circuit. This finding was most evident when an active heating system was mounted between those points. Conclusions The concentrations of NO and NO2 should be measured as near to the patient as possible as significant fluctuations of these concentrations might be found along the inspiratory limb of the respiratory circuit especially when an active heating system is used. Addresses Department of Anaesthesiology University Hospital Medical School RWTH Aachen Germany. Department of Anaesthesiology and Intensive Care Medicine Virchow Hospital Medical School Humboldt University Berlin Germany. Correspondence Ralf Kuhlen MD Department of Anaesthesiology University Hospital Medical School RWTH Aachen Pauwelsstr. 30 52074 Aachen Germany. Tel 49-241-80-88179 Fax 49-241-8888-406 Email This study was supported by DFG Fa139 4-1. Keywords acute lung injury mechanical ventilation nitric oxide Received 21 July 1997 Revisions requested 3 November 1997 .

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