TAILIEUCHUNG - Báo cáo y học: " Obstructive sleep apnea and vascular disease Paola Lanfranchi and Virend K Somers"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:Obstructive sleep apnea and vascular disease Paola Lanfranchi and Virend K Somers. | Available online http content 2 6 315 Commentary Obstructive sleep apnea and vascular disease Paola Lanfranchi and Virend K Somers Mayo Clinic Rochester Minnesota USA Correspondence Virend K Somers MD DPhil Mayo Clinic 200 First Street SW DO 4-350 Rochester MN 55905 USA. Tel 1 507 255 1144 fax 1 507 255 7070 e-mail o 3 I Received 23 April 2001 Revisions requested 11 June 2001 Revisions received 3 July 2001 Accepted 19 July 2001 Published 21 August 2001 Respir Res 2001 2 315-319 2001 BioMed Central Ltd Print ISSN 1465-9921 Online ISSN 1465-993X Abstract There is emerging evidence linking obstructive sleep apnea OSA to vascular disease including hypertension. This relationship may be independent of co-morbidity such as obesity. Even apparently healthy OSA patients have evidence of subtle functional vascular abnormalities that are known to occur in patients with hypertension and atherosclerosis. Untreated OSA may possibly contribute to the initiation and or progression of pathophysiologic mechanisms involved in hypertension heart failure cardiac ischemia and stroke. This brief commentary will examine the evidence and mechanisms linking OSA to vascular disease. Keywords cardiovascular risk hypertension sleep apnea sympathetic nervous system vascular disease Introduction Our understanding of OSA has evolved from regarding it as an interesting and occasionally annoying social curiosity to the recognition that OSA may act through various mechanisms to increase morbidity and mortality 1 . The health consequences of sleep apnea are especially evident in the cardiovascular system where it is becoming increasingly apparent that untreated OSA may have direct and deleterious effects on cardiac and vascular structure and function. These effects may include subtle and sub-clinical impairment of normal homeostatic regulation such as impaired baroreflex 2 and chemoreflex 3 functions and elevated nocturnal blood pressure in sleep apnea

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