TAILIEUCHUNG - Báo cáo khoa học " Structure and anti-tumor activity of a high-molecular-weight polysaccharide from cultured mycelium of Cordyceps gunnii "

Cordyceps gunnii (berk.) Berk (C. Gunnii) is well known as a Chinese rare caterpillar fungus and has similar pharmacological activity with C. sinensis. In this work, a high-molecular-weight polysaccharide (CPS) was isolated and purified from the mycelia of C. gunnii. The total sugar content of CPS was amounted to . The result of HPLC indicated that CPS was a homogeneous polysaccharide. The estimated average molecular weight of CPS was ×106 Da. The specific rotation of CPS was recorded [˛]25 D = +◦. Its characteristic was determined by chemical analysis, gas chromatography, IR spectroscopy and NMR data. The results showed that CPS was mainly composed of glucose,. | Carbohydrate Polymers 88 2012 1072-1076 Contents lists available at SciVerse ScienceDirect Carbohydrate Polymers journal homepage locate carbpol Structure and anti-tumor activity of a high-molecular-weight polysaccharide from cultured mycelium of Cordyceps gunnii Zhen-yuan Zhua Nian Liua Chuan-ling Sib Yang Liua Li-na Dinga Chen Jinga An-jun Liua Yong-min Zhangc a Key Laboratory of Food Nutrition and Safety Ministry of Education College of Food Science and Biotechnology Tianjin University of Science and Technology Tianjin 300457 PR China b Tianjin Key Laboratory of Pulp and Paper College of Materials Science and Chemical Engineering Tianjin University of Science and Technology Tianjin 300457 PR China c Université Pierre et Marie Curie-Paris 6 Institut Parisien de Chimie Moléculaire UMR CNRS 7201 4 Place Jussieu 75005 Paris France ARTICLE INFO ABSTRACT Article history Received 12 December 2011 Received in revised form 15 January 2012 Accepted 20 January 2012 Available online 28 January 2012 Keywords Cordyceps gunnii High-molecular-weight polysaccharide Characteristic Antitumor Cordycepsgunnii berk. Berk C. Gunnii is well known as a Chinese rare caterpillar fungus and has similar pharmacological activity with C. sinensis. In this work a high-molecular-weight polysaccharide CPS was isolated and purified from the mycelia of C. gunnii. The total sugar content of CPS was amounted to . The result of HPLC indicated that CPS was a homogeneous polysaccharide. The estimated average molecular weight of CPS was X 106 Da. The specific rotation of CPS was recorded a D5 . Its characteristic was determined by chemical analysis gas chromatography IR spectroscopy and NMR data. The results showed that CPS was mainly composed of glucose and a small amount of rhamnose arabinose xylose mannose and galactose with a molar ratio of Rha Ara Xyl Man Glu Gal . The main chain of CPS was majorly composed of a- 1 4 glucose. The tumor .

• Báo cáo khoa học
• Cordyceps gunnii
• High molecular weight
• polysaccharide
• Characteristic
• Antitumo
• Carbohydrate Polymers
• Helicobacter pylori
• Mass spectrometry
• Carbohydrate microarrays
• Host immune receptors
• Lignin carbohydrate complexes
• Fenton oxidation
• Hydrothermal treatment
• Enzymatic hydrolysis
• Natural polymers
• Cellulose derivatives
• Cellulose nanocrystals
• Natural polymers assemblies
• Plant polysaccharides
• Reactive extrusion
• Fossil based polymeric materials
• Biobased polymers
• Bioinspired materials
• Fungal glycobiology
• Carbohydrate biopolymers
• Food applications
• Spectra interpretation
• Spectra processing
• Chemical shifts analysis
• Nuclear Magnetic Resonance
• Functional carbohydrate
• Glass transition temperature
• Wall material
• Water adsorption isotherms
• Glycan arrays
• Fermentation process
• Complex polysaccharides
• Carbohydrate microarray technology
• Achira starch
• Polymeric blend films
• Synthetic polymers
• Xray diffraction
• Bio based latex
• Packaging application
• Low oxygen permeability
• Bacterial cellulose
• Cellulosic aerogels
• Cellulose composite materials
• Interpenetrating polymer networks
• Supercritical carbon dioxide
• Low solubility
• Ternary systems
• Inclusion complex
• Delivery systems
• Hyaluronic acid
• Cancer cells
• Somatic cells
• Anionic polymers
• Human mesenchymal stem cell
• Thermoplastic starch
• Thermoplastic chitosan
• Biodegradable polymers
• Scanning Electron Microscopy
• Associating polysaccharides
• Salt sensitive
• Smart polymers
• Ethylene oxide
• Propylene oxide
• Betamethasone 17 valerate
• Aphthous stomatitis
• Polymeric blends
• Polymers chitosan
• In vitro fecal fermentation
• Short chain fatty acids
• Consequent nutritional
• Parabacteroides distasonis
• Mucosal drug delivery
• S protected thiomers
• Thiolated polymer
• Mucoadhesive polymers
• Cordyceps militaris
• Immunostimulating polysaccharide
• Macrophage activation
• Random coil conformation
• natural polysaccharides
• Kinetic model
• Modified shrinking core model
• Diffusion limited kinetics
• Heterogeneous deacetylation
• 3D printing
• Anisotropic actuation
• Anti bacterial properties
• Bacterial eradication
• Lipid based vesicle
• Skin therapy
• Membrane active antimicrobials
• Calcium alginate networks
• Heterogeneity crosslinking
• Barrier properties
• Mechanical properties
• Life Cycle Assessment
• Carbon emission
• Cellulosic fiber materials
• Polyethylene terephthalate
• Human serum
• Red algae
• β galactose moiety
• Hybrid structures