TAILIEUCHUNG - Báo cáo y học: " Elevated endotoxin levels in non-alcoholic fatty liver disease"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Elevated endotoxin levels in non-alcoholic fatty liver disease. | Harte et al. Journal of Inflammation 2010 7 15 http content 7 1 15 JOURNAL OF INFLAMMATION RESEARCH Open Access Elevated endotoxin levels in non-alcoholic fatty liver disease Alison L Harte 41 Nancy F da Silva11 Steven J Creely 1 Kirsty C McGee1 Thomas Billyard1 Elham M Youssef-Elabd2 Gyanendra Tripathi1 Esmat Ashour2 Mohga S Abdalla3 Hayat M Sharada3 Ashraf I Amin4 Alastair D Burt5 Sudhesh Kumar1 Christopher P Day5 and Philip G McTernan1 Abstract Background Emerging data indicate that gut-derived endotoxin may contribute to low-grade systemic inflammation in insulin resistant states. This study aimed to examine the importance of serum endotoxin and inflammatory markers in non-alcoholic fatty liver disease NAFLD patients with and without type 2 diabetes mellitus T2DM and to explore the effect of treatment with a lipase inhibitor Orlistat on their inflammatory status. Methods Fasted serum from 155 patients with biopsy proven NAFLD and 23 control subjects were analysed for endotoxin soluble CD14 sCD14 soluble tumour necrosis factor receptor II sTNFRII and various metabolic parameters. A subgroup of NAFLD patients were re-assessed 6 and 12 months after treatment with diet alone n 6 or diet plus Orlistat n 8 . Results Endotoxin levels were significantly higher in patients with NAFLD compared with controls NAFLD EU mL controls EU mL p NAFLD alone produced comparable endotoxin levels to T2DM NAFLD T2DM EU mL non-diabetic EU mL whilst a significant correlation between insulin resistance and serum endotoxin was observed r p . Both sCD14 p and sTNFRII p increased with severity of fibrosis. A positive correlation was also noted between sTNFRII and sCD14 in the NAFLD subjects r p . Sub-cohort treatment with Orlistat in patients with NAFLD showed significant decreases in ALT p weight p and endotoxin p compared with the NAFLD non-Orlistat .

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