TAILIEUCHUNG - Báo cáo sinh học: " Stability of multiple alignments and phylogenetic trees: an analysis of ABC-transporter proteins family"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí y học Molecular Biology cung cấp cho các bạn kiến thức về ngành sinh học đề tài: Stability of multiple alignments and phylogenetic trees: an analysis of ABC-transporter proteins family. | Algorithms for Molecular Biology BioMed Central Open Access Short report Stability of multiple alignments and phylogenetic trees an analysis of ABC-transporter proteins family Holger Wagner1 Burkhard Morgenstern 2 and Andreas Dress3 4 Address 1FSPM Faculty of Mathematics Bielefeld University Postfach 100131 D-33501 Bielefeld Germany institute of Microbiology and Genetics University of Gottingen Goldschmidtstr. 1 D-37077 Gottingen Germany 3CAS-MPG Partner Institute for Computational Biology 320 Yue Yang Road 200031 Shanghai PR China and 4Max Planck Institute for Mathematics in the Sciences Inselstrasse 22 - 26 D-04103 Leipzig Germany Email Holger Wagner - h_wagner@ Burkhard Morgenstern - bmorgen@ Andreas Dress - andreas@ Corresponding author Published 6 November 2008 Received 30 April 2008 Algorithms for Molecular Biology 2008 3 15 doi 1748-7188-3-15 Accepted 6 November 2008 This article is available from http content 3 1 15 2008 Wagner et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background Sequence-based phylogeny reconstruction is a fundamental task in Bioinformatics. Practically all methods for phylogeny reconstruction are based on multiple alignments. The quality and stability of the underlying alignments is therefore crucial for phylogenetic analysis. Results In this short report we investigate alignments and alignment-based phylogenies constructed for a set of 22 ABC transporters using CLUSTAL W and DIALIGN. Comparing the 22 one-out phylogenies one can obtain for this sequence set some intrinsic phylogenetic instability is observed even if attention is restricted to .

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