TAILIEUCHUNG - THE PROTEIN DATA BANK

An important function of the Federal Reserve is ensuring that enough cash—that is, currency and coin—is in circulation to meet the public’s demand. When Congress established the Federal Reserve, it recognized that the public’s demand for cash is variable. This demand increases or decreases seasonally and as the level of economic activity changes. For example, in the weeks leading up to a holiday season, depository institu- tions increase their orders of currency and coin from Reserve Banks to meet their customers’ demand. Following the holiday season, depository institutions ship excess currency and coin back to the Reserve. | 2000 Oxford University Press Nucleic Acids Research 2000 Vol. 28 No. 1 235-242 The Protein Data Bank Helen M. Berman1 2 John Westbrook1 2 Zukang Feng1 2 Gary Gilliland1 3 T. N. Bhat1 3 Helge Weissig1 4 Ilya N. Shindyalov4 and Philip E. Bourne1 4 5 6 1Research Collaborator for Structural Bioinformatics RCSB 2Department of Chemistry Rutgers University 610 Taylor Road Piscataway NJ 08854-8087 USA 3National Institute of Standards and Technology Route 270 Quince Orchard Road Gaithersburg MD 20899 USA 4San Diego Supercomputer Center University of California San Diego 9500 Gilman Drive La Jolla CA 92093-0505 USA 5Department of Pharmacology University of California San Diego 9500 Gilman Drive La Jolla CA 92093-0500 USA and 6The Burnham Institute 10901 North Torrey Pines Road La Jolla CA 92037 USA Received September 20 1999 Revised and Accepted October 17 1999 ABSTRACT The Protein Data Bank PDB http pdb is the single worldwide archive of structural data of biological macromolecules. This paper describes the goals of the PDB the systems in place for data deposition and access howto obtain further information and near-term plans forthe future development of the resource. INTRODUCTION The Protein Data Bank PDB was established at Brookhaven National Laboratories BNL 1 in 1971 as an archive for biological macromolecular crystal structures. In the beginning the archive held seven structures and with each year a handful more were deposited. In the 1980s the number of deposited structures began to increase dramatically. This was due to the improved technology for all aspects of the crystallographic process the addition of structures determined by nuclear magnetic resonance NMR methods and changes in the community views about data sharing. By the early 1990s the majority of journals required a PDB accession code and at least one funding agency National Institute of General Medical Sciences adopted the guidelines published by the International Union of Crystallography .

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