TAILIEUCHUNG - Báo cáo y học: " Muscarinic receptor signaling in the pathophysiology of asthma and COPD"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Muscarinic receptor signaling in the pathophysiology of asthma and COPD. | Respiratory Research BioMed Central Review Open Access Muscarinic receptor signaling in the pathophysiology of asthma and COPD Reinoud Gosens 1 2 3 Johan Zaagsma1 Herman Meurs1 and Andrew J Halayko2 3 Address Department of Molecular Pharmacology University of Groningen Groningen The Netherlands 2Departments of Physiology Internal Medicine University of Manitoba Winnipeg MB Canada and 3Biology of Breathing Group Manitoba Institute of Child Health Winnipeg MB Canada Email Reinoud Gosens - rgosens@ Johan Zaagsma - Herman Meurs - Andrew J Halayko - ahalayk@ Corresponding author Published 09 May 2006 Received 03 March 2006 Respiratory Research 2006 7 73 doi 1465-9921-7-73 Accepted 09 May 2006 This article is available from http content 7 1 73 2006 Gosens et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Anticholinergics are widely used for the treatment of COPD and to a lesser extent for asthma. Primarily used as bronchodilators they reverse the action of vagally derived acetylcholine on airway smooth muscle contraction. Recent novel studies suggest that the effects of anticholinergics likely extend far beyond inducing bronchodilation as the novel anticholinergic drug tiotropium bromide can effectively inhibit accelerated decline of lung function in COPD patients. Vagal tone is increased in airway inflammation associated with asthma and COPD this results from exaggerated acetylcholine release and enhanced expression of downstream signaling components in airway smooth muscle. Vagally derived acetylcholine also regulates mucus production in the airways. A number of recent research papers also indicate that acetylcholine acting .

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