TAILIEUCHUNG - Báo cáo y học: "Mannose-binding lectin does not explain the course and outcome of pregnancy in rheumatoid arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Mannose-binding lectin does not explain the course and outcome of pregnancy in rheumatoid arthritis. | van de Geijn et al. Arthritis Research Therapy 2011 13 R10 http content 13 1 R10 RESEARCH ARTICLE Open Access Mannose-binding lectin does not explain the course and outcome of pregnancy in rheumatoid arthritis 1 1 2 3 2 Fleur E van de Geijn Yael A de Man Manfred Wuhrer Sten P Willemsen André M Deelder Johanna MW Hazes1 Radboud JEM Dolhain1 Abstract Introduction Rheumatoid arthritis RA improves during pregnancy and flares after delivery. It has been hypothesized that high levels of the complement factor mannose-binding lectin MBL are associated with a favourable disease course of RA by facilitating the clearance of pathogenic immunoglobulin G IgG lacking galactose sugar moieties. During pregnancy increased galactosylation of IgG and simultaneously increased MBL levels can be observed with the latter being strictly related to maternal MBL genotypes. Therefore increased MBL levels in concert with increased IgG galactosylation may be associated with pregnancy-induced improvement of RA. The objective of this study was to investigate whether MBL genotypes are associated with changes in RA disease activity and with changes in IgG galactosylation during pregnancy and in the postpartum period. We also studied the association between MBL genotypes and pregnancy outcomes in RA. Methods Serum from 216 patients with RA and 31 healthy controls participating in the Pregnancy-induced Amelioration of Rheumatoid Arthritis PARA Study was collected before during and after pregnancy. IgG galactosylation was determined by performing matrix-assisted laser desorption ionization time of flight mass spectrometry. Disease activity was determined using the internationally recognized Disease Activity Score 28 DAS28 . MBL genotypes were determined. The pregnancy outcome measures studied were gestational age birth weight miscarriage and hypertensive disorders. Results No association was found between the MBL genotype groups and changes in RA disease activity P or .

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