TAILIEUCHUNG - Báo cáo khoa học: Mechanisms of obesity and related pathologies: Role of apolipoprotein E in the development of obesity

Apolipoprotein E is a polymorphic glycoprotein in humans with a molecu-lar mass of kDa. It is a component of chylomicron remnants, very low density lipoprotein, low density lipoprotein and high density lipopro-tein, and is primarily responsible for maintaining plasma lipid homeostasis. In addition to these well-documented functions, recent studies in experi-mental mouse models, as well as population studies, show that apolipo-protein E also plays an important role in the development of obesity and insulin resistance. . | MINIREVIEW Mechanisms of obesity and related pathologies Role of apolipoprotein E in the development of obesity Kyriakos E. Kypreos1 lordanes Karagiannides2 Elisavet H. Fotiadou1 Eleni A. Karavia1 Maria S. Brinkmeier1 Smaragda M. Giakoumi1 and Eirini M. Tsompanidi1 1 Department of Medicine Pharmacology Unit University of Patras Medical School Rio Greece 2 Department of Medicine David Geffen Schoolof Medicine UCLA Los Angeles CA USA Keywords ApoE receptors ApoE3knock-in mice ApoE4knock-in mice ApoE-deficient mice apolipoprotein E glucose intolerance insulin resistance metabolic syndrome obesity Correspondence K. E. Kypreos Department of Medicine University of Patras Medical School Pharmacology Unit Panepistimioupolis Rio TK 26500 Greece Fax 30 2610994720 Tel 30 2610969120 E-mail kkypreos@ Received 18 February 2009 revised 1 August 2009 accepted 11 August 2009 doi Apolipoprotein E is a polymorphic glycoprotein in humans with a molecular mass of kDa. It is a component of chylomicron remnants very low density lipoprotein low density lipoprotein and high density lipoprotein and is primarily responsible for maintaining plasma lipid homeostasis. In addition to these well-documented functions recent studies in experimental mouse models as well as population studies show that apolipoprotein E also plays an important role in the development of obesity and insulin resistance. It is widely accepted that disruption in homeostasis between food intake and energy expenditure and the subsequent deposition of excess fatty acids into fat cells in the form of triglycerides leads to the development of obesity. Despite the pivotal role of obesity and dyslipidemia in the development of the metabolic syndrome and heart disease the functional interactions between adipose tissue and components of the lipoprotein transport system have not yet been investigated thoroughly. In this minireview we focus on the current literature pertinent to .

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