TAILIEUCHUNG - Báo cáo y học: " Corticosteroid effects on ventilator-induced diaphragm dysfunction in anesthetized rats depend on the dose administered"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Corticosteroid effects on ventilator-induced diaphragm dysfunction in anesthetized rats depend on the dose administered. | Maes et al. Respiratory Research 2010 11 178 http content 11 1 178 RESPIRATORY RESEARCH RESEARCH Open Access Corticosteroid effects on ventilator-induced diaphragm dysfunction in anesthetized rats depend on the dose administered 112 2 1 1 Karen Maes Anouk Agten Ashley Smuder Scott K Powers Marc Decramer Ghislaine Gayan-Ramirez Abstract Background High dose of corticosteroids has been previously shown to protect against controlled mechanical ventilation CMV -induced diaphragmatic dysfunction while inhibiting calpain activation. Because literature suggests that the calpain inhibiting effect of corticosteroid depends on the dose administered we determined whether lower doses of corticosteroids would also provide protection of the diaphragm during CMV. This may be important for patients undergoing mechanical ventilation and receiving corticosteroids. Methods Rats were assigned to controls or to 24 hours of CMV while being treated at the start of mechanical ventilation with a single intramuscular administration of either saline or 5 mg kg low MP or 30 mg kg high MP of methylprednisolone. Results Diaphragmatic force was decreased after CMV and this was exacerbated in the low MP group while high MP rescued this diaphragmatic dysfunction. Atrophy was more severe in the low MP group than after CMV while no atrophy was observed in the high MP group. A significant and similar increase in calpain activity was observed in both the low MP and CMV groups whereas the high dose prevented calpain activation. Expression of calpastatin the endogenous inhibitor of calpain was decreased in the CMV and low MP groups but its level was preserved to controls in the high MP group. Caspase-3 activity increased in all CMV groups but to a lesser extent in the low and high MP groups. The 20S proteasome activity was increased in CMV only. Conclusions Administration of 30 mg kg methylprednisolone during CMV protected against CMV-induced diaphragm dysfunction while 5 mg kg

TỪ KHÓA LIÊN QUAN
Đã phát hiện trình chặn quảng cáo AdBlock
Trang web này phụ thuộc vào doanh thu từ số lần hiển thị quảng cáo để tồn tại. Vui lòng tắt trình chặn quảng cáo của bạn hoặc tạm dừng tính năng chặn quảng cáo cho trang web này.