TAILIEUCHUNG - Báo cáo khoa học: Apoptosis and autophagy: Targeting autophagy signalling in cancer cells – ‘trick or treats’?

Macroautophagy (hereafter referred to as autophagy) is a tightly regulated lysosome-dependent catabolic pathway. During this process, cytosolic con-stituents are sequestered into autophagosomes, which subsequently fuse with lysosomes to become autolysosomes, where their contents are degraded. | MINIREVIEW Apoptosis and autophagy Targeting autophagy signalling in cancer cells - trick or treats Elisabeth A. Corcelle Pietri Puustinen and Marja Jaattela Apoptosis Department and Centre for Genotoxic Stress Research Institute of Cancer Biology Danish Cancer Society Copenhagen Denmark Keywords autophagy cancer kinases phosphatases signalling therapy Correspondence M. UỄỈỂittelỄs Department of Apoptosis Institute of Cancer Biology Danish Cancer Society Strandboulevarden 49 DK-2100 Copenhagen Denmark Fax 45 35257721 Tel 45 35257318 E-mail mj@ Received 23 March 2009 revised 9 July 2009 accepted 24 July 09 doi Macroautophagy hereafter referred to as autophagy is a tightly regulated lysosome-dependent catabolic pathway. During this process cytosolic constituents are sequestered into autophagosomes which subsequently fuse with lysosomes to become autolysosomes where their contents are degraded. Autophagy contributes to the maintenance of the cellular energy homeostasis to the clearance of damaged organelles and to adaptation to environmental stresses. Accordingly autophagy defects have been linked to a wide range of human pathologies including cancer. The recent discovery of several evolutionarily conserved genes involved in autophagosome formation has greatly stimulated the autophagy research and the complex signalling networks regulating mammalian autophagy have begun to emerge. Here we draw the current picture of signalling pathways connecting mitogenic and stress-induced signals to the initiation and maturation of autophagosomes and discuss the possibilities of their targeting as therapeutic adjuvants in anticancer therapy. Introduction Macroautophagy hereafter referred to as autophagy is an evolutionarily conserved lysosomal self-digestion process responsible for the turnover of whole organelles and macromolecules 1 2 . In addition to important housekeeping functions autophagy promotes the survival of starved and stressed

• Báo cáo khoa học
• scientific reports
• thesis report
• medical report
• Structural biochemistry
• oxidation
• bacteria
• collection of scientific reports
• industry reports philosophy of history reports
• reports in literature
• a scientific b shirt
• presentation of scientific reports
• reports on literature
• philosophy statement
• documents
• studies English language and English language communication and English language commercial
• progress reports at scientific collections
• agronomic reports
• reports in physics
• biology reports
• thematic biological
• induced geometry
• mathematical topics
• quantum mechanics
• physics
• reporting mathematics
• physics reports
• livestock reports
• physical reports
• research physicist
• specializing in physics
• mathematical statements
• mathematical equations
• English pronunciation
• presentation report
• agricultural reports
• technical crops
• bio technology
• English reports
• scientific research
• presentation reports
• mathematical knowledge
• reports of mathematics
• represented
• Wilf on packing distinct
• Tur´n density
• mathematical works
• patterns in a permutation
• statements and documents scientific reports
• reports agronomy
• biotechnology
• plants Vietnam
• specialized biological
• microbiological methods
• presenting the report
• anti bacterial properties of shrimp
• energy exchange
• engineering chicken
• Path counting
• random matrix theory
• Even circuits
• prescribed clockwise parity
• Correspondence between
• algorithmic characterizations
• Finding Induced Acyclic
• Random Digraphs
• Nonexistence results
• Hadamard like matrices
• Voltage Graphs
• Group Presentations
• Cages mathematical knowledge
• Dominance Order
• Graphical Partitions
• On the functions
• values in [α(G
• Box With Translates
• Two Given Rectangular Brick
• On the q analogue
• the sum of cubes