TAILIEUCHUNG - Prevalence of Pulmonary tuberculosis and immunological profile of HIV co-infected patients in Northwest Ethiopia

In sub-Saharan Africa, as high as 2/3 of tuberculosis patients are HIV/AIDS co-infected and tuberculosis is the most common cause of death among HIV/AIDS patients worldwide. Tuberculosis and HIV co-infections are associated with special diagnostic and therapeutic challenges and constitute an immense burden on healthcare systems of heavily infected countries like Ethiopia. The aim of the study was to determine the prevalence of pulmonary tuberculosis and their immunologic profiles among HIV positive patients. Methods: A cross sectional study was conducted among adult HIV-positive patients attending HIV/AIDS clinic of Gondar University Hospital. Clinical and laboratory investigations including chest x-ray and acid fast staining were used to identify tuberculosis. | Wondimeneh et al. BMC Research Notes 2012 5 331 http 1756-0500 5 331 BMC Research Notes RESEARCH ARTICLE Open Access Prevalence of Pulmonary tuberculosis and immunological profile of HIV co-infected patients in Northwest Ethiopia Yitayih Wondimeneh1 Dagnachew Muluye2 and Yeshambel Belyhun3 Abstract Background In sub-Saharan Africa as high as 2 3 of tuberculosis patients are HIV AIDS co-infected and tuberculosis is the most common cause of death among HIV AIDS patients worldwide. Tuberculosis and HIV co-infections are associated with special diagnostic and therapeutic challenges and constitute an immense burden on healthcare systems of heavily infected countries like Ethiopia. The aim of the study was to determine the prevalence of pulmonary tuberculosis and their immunologic profiles among HIV positive patients. Methods A cross sectional study was conducted among adult HIV-positive patients attending HIV AIDS clinic of Gondar University Hospital. Clinical and laboratory investigations including chest x-ray and acid fast staining were used to identify tuberculosis cases. Blood samples were collected to determine CD4 lymphocyte count. A structured questionnaire was used to collect socio-demographic characteristics of study subjects. The data was entered and analyzed using SPSS version 16 software. Results A total of 400 HIV positive study participants were enrolled. Thirty 95 CI of the study participants were found to have pulmonary tuberculosis. In multivariate analysis only CD4 lymphocyte count AOR 95 CI was found to be independently associated with tuberculosis-HIV co-infection. Individuals who had advanced WHO clinical stage were also statistically significant for co-infection. The mean CD4 lymphocyte count of HIV mono-infected participants were 296 192 Cells mm3 and tuberculosis-HIV co-infected patients had mean CD4 lymphocyte count of 199 149 Cells mm3 with p value of . Conclusions We found high prevalence

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