TAILIEUCHUNG - Immunology of tuberculosis

2004Tuberculosis is a major health problem throughout the world causing large number of deaths,more than that from any other single infectious disease. The review attempts to summarize theinformation available on host immune response to Mycobacterium tuberculosis. Since the mainroute of entry of the causative agent is the respiratory route, alveolar macrophages are theimportant cell types, which combat the pathogen. Various aspects of macrophage-mycobacteriuminteractions and the role of macrophage in host response such as binding of M. tuberculosis tomacrophages via surface receptors, phagosome-lysosome fusion, mycobacterial growthinhibition/killing through free radical based mechanisms such as reactive oxygen and nitrogenintermediates; cytokine-mediated mechanisms; recruitment of. | Review Article Indian J Med Res 120 October 2004 pp 213-232 Immunology of tuberculosis Alamelu Raja Department of Immunology Tuberculosis Research Centre ICMR Chennai India Received April 8 2004 Tuberculosis is a major health problem throughout the world causing large number of deaths more than that from any other single infectious disease. The review attempts to summarize the information available on host immune response to Mycobacterium tuberculosis. Since the main route of entry of the causative agent is the respiratory route alveolar macrophages are the important cell types which combat the pathogen. Various aspects of macrophage-mycobacterium interactions and the role of macrophage in host response such as binding of M. tuberculosis to macrophages via surface receptors phagosome-lysosome fusion mycobacterial growth inhibition killing through free radical based mechanisms such as reactive oxygen and nitrogen intermediates cytokine-mediated mechanisms recruitment of accessory immune cells for local inflammatory response and presentation of antigens to T cells for development of acquired immunity have been described. The role of macrophage apoptosis in containing the growth of the bacilli is also discussed. The role of other components of innate immune response such as natural resistance associated macrophage protein Nramp neutrophils and natural killer cells has been discussed. The specific acquired immune response through CD4 T cells mainly responsible for protective Th1 cytokines and through CD8 cells bringing about cytotoxicity also has been described. The role of CD-1 restricted CD8 T cells and non-MHC restricted y S T cells has been described although it is incompletely understood at the present time. Humoral immune response is seen though not implicated in protection. The value of cytokine therapy has also been reviewed. Influence of the host human leucocyte antigens HLA on the susceptibility to disease is discussed. Mycobacteria are endowed with .

• Y học thường thức
• Advanced Therapies
• Celiac Disease
• Renal Replacement
• Uremic Diabetic
• Patients – Experience
• Republic of Macedonia
• Celiac
• Pathophysiology
• Therapies
• by Peter Kruzliak
• Govind Bhagat
• Health
• Sciences
• medicine
• pharmacolocy
• BMC Cancer
• Advanced NSCLC
• Licensed drugs
• Targeted therapies
• Check point inhibitors
• Advanced melanoma
• L1 blockade
• CTLA 4 blockade
• BRAF inhibitor
• MEK inhibitor
• Overall survival
• Quality of life
• Subsequent therapy
• Coeliac Disease Patients
• Using Monoclonal Antibodies
• Main Immunogenic
• Gluten Peptide
• Laboratory Methods
• Toxic Peptides
• Sensitive Detection
• Antioxidant Status
• Multiple Sclerosis
• Diabetes Mellitus Type
• Clinical Manifestations
• Coeliac Disease
• Angiotensin converting
• combination therapies
• Health Action International
• Plant Heavy
• Metal Interaction
• Water Relations
• workplace contribution