TAILIEUCHUNG - báo cáo hóa học:" Predictors of health status do not change over three-year periods and exacerbation makes difference in chronic obstructive pulmonary disease"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí hóa học đề tài : Predictors of health status do not change over three-year periods and exacerbation makes difference in chronic obstructive pulmonary disease | Ferrari et al. Health and Quality of Life Outcomes 2011 9 112 http content 9 1 112 HEALTH AND QUALITY OF LIFE OUTCOMES RESEARCH Open Access Predictors of health status do not change over three-year periods and exacerbation makes difference in chronic obstructive pulmonary disease Renata Ferrari Suzana E Tanni Laura MO Caram Cristiane R Naves and Irma Godoy Abstract Background The association between disease markers and health status HS overtime is unclear. The aim of this study was to verify the predictors of HS at baseline and after three years in Chronic Obstructive Pulmonary Disease COPD patients. Methods Ninety-five consecutive COPD patients 66 male age 67 9 y FEV1 58 23 underwent the following evaluations at baseline and after three years body composition pulse oximetry SpO2 six-minute walk distance 6MWD Modified edical Research Council dyspnea scale MMRC and Saint George s Respiratory Questionnaire SGRQ . The Charlson comorbidity index and BODE index were calculated. COPD exacerbations during the follow-up were evaluated. At baseline age gender smoking SpO2 BODE index or its components BMI MMRC FEV1 and 6MWD and Charlson index were included in a multiple linear regression analysis with the baseline SGRQ total score as the dependent variable. After three years we included the final values of the variables plus the number of exacerbations and the final SGRQ total score as the dependent variable. Results SGRQ total score 42 19 vs 44 19 p and activity domain 52 21 vs 60 22 p deteriorated during follow-up. At baseline BODE index was selected as a predictor of SGRQ total score R2 p after three years BODE index and age were the predictors R2 p . When the BODE index was replaced by its variables MMRC was selected as the only variable associated with the SGRQ total score R2 p . After three years MMRC FEV1 and number of exacerbations were selected as predictors of SGRQ total score R2 p . Conclusion HS

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