TAILIEUCHUNG - Báo cáo khoa học: Amyloid oligomers: diffuse oligomer-based transmission of yeast prions

Prions are infectious proteins, in which self-propagating amyloid conforma-tions of proteins are transmitted. The budding yeast Saccharomyces cerevi-siae, one of the best-studied model eukaryotes, also has prions, and thus provides a tractable model system with which to understand the mechanisms of prion phenomena. | MINIREVIEW Amyloid oligomers diffuse oligomer-based transmission of yeast prions Hideki Taguchi and Shigeko Kawai-Noma Department of MedicalGenome Sciences Graduate Schoolof Frontier Sciences University of Tokyo Kashiwanoha Kashiwa Chiba Japan Keywords amyloid fluorescence correlation spectroscopy prion Sup35 yeast prion Correspondence H. Taguchi Department of MedicalGenome Sciences Graduate School of Frontier Sciences University of Tokyo FSB401 5-1-5 Kashiwanoha Kashiwa Chiba 277-8562 Japan Fax 81 4 7136 3644 Tel 81 4 7136 3644 E-mail taguchi@ Received 4 September 2009 revised 24 November 2009 accepted 25 November 2010 Prions are infectious proteins in which self-propagating amyloid conformations of proteins are transmitted. The budding yeast Saccharomyces cerevi-siae one of the best-studied model eukaryotes also has prions and thus provides a tractable model system with which to understand the mechanisms of prion phenomena. The yeast prions are protein-based heritable elements such as PSI in which aggregates of prion proteins are transmitted to daughter cells in a non-Mendelian manner. Although the genetic approaches preceded the yeast prion studies recent investigations of the dynamic aspects of the prion proteins have unraveled the molecular mechanisms by which prions are propagated and transmitted. In particular several lines of evidence have revealed that the oligomeric species of prion proteins dispersed in the cytoplasm are critical for the transmission. This review summarizes the topics on the transmissible entities of yeast prions focusing mainly on the Sup35 protein in PSI . doi Introduction Scrapie in sheep bovine spongiform encephalopathy also called mad cow disease in cattle and Creutzfeldt-Jakob disease in humans are transmissible spongiform encephalopathies which are also called prion diseases. A prion is a proteinaceous infectious particle that lacks nucleic acids which means that it is an infectious

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