TAILIEUCHUNG - báo cáo hóa học:" Relationships between changes in pain severity and other patient-reported outcomes: an analysis in patients with posttraumatic peripheral neuropathic pain"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí hóa học đề tài : Relationships between changes in pain severity and other patient-reported outcomes: an analysis in patients with posttraumatic peripheral neuropathic pain | van Seventer et al. Health and Quality of Life Outcomes 2011 9 17 http content 9 1 17 HEALTH AND QUALITY OF LIFE OUTCOMES RESEARCH Open Access Relationships between changes in pain severity and other patient-reported outcomes an analysis in patients with posttraumatic peripheral neuropathic pain D L Z r z-s c z-kt Fz r 1h ỉ I r L f I c r r I I 2 D I f Y Ý Y Ý I Z1 KỈ D s r h3 4 Dn rh h K r z I I r z 5 7 I s Fz x z -s6 Robert van Seventer Michael Serpeii Fiemming W Bach Dari Mornon Gergana Ziateva Andrew G Bushmakin7 Joseph C Cappeiieri7 and Meryem Nimour8 Abstract Background The objective of this study is to use the pain numeric rating scaie NRS to evaiuate associations between change in pain severity and changes in sieep function and mood assessed via patient-reported outcomes PROs in patients with posttraumatic pain. Methods This is a secondary anaiysis of a ciinicai triai evaiuating pregabaiin in patients with posttraumatic peripherai neuropathic pain N 254 . Regression modeis were used to determine associations between changes in pain 0-10 NRS as the predictor and scores on the foiiowing PRO measures as the outcome Pain Interference Index Hospitai Anxiety and Depression Scaie anxiety and depression subscaies Medicai Outcomes Study-Sieep Scaie 9-item Sieep Probiems Index and Sieep Disturbance subscaie and Daiiy Sieep Interference Scaie 0-10 NRS . Results Change in pain severity showed ciear direct reiationships with changes in function anxiety depression and sieep PROs aii of which were statisticaiiy significant P .001 . Resuits from subgroup anaiyses 30 or 50 pain responders pregabaiin or piacebo treatment age 51 years or 51 years tended to be consistent with resuits from the overaii sampie. Conclusions Overaii a direct reiationship exists between pain and various aspects of patient s weii-being and functioning which can provide a quantitative assessment of how improvements in pain may be expected to reiate to other patient outcomes. http .

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