TAILIEUCHUNG - báo cáo khoa học: "Transient myeloproliferative disorder in a newborn with Down Syndrome treated with rasburicase for the risk of development of tumor lysis syndrome: A case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Transient myeloproliferative disorder in a newborn with Down Syndrome treated with rasburicase for the risk of development of tumor lysis syndrome: A case report | Tragiannidis et al. Journal of Medical Case Reports 2011 5 407 http content 5 1 407 JOURNAL OF MEDICAL CASE REPORTS CASE REPORT Open Access Transient myeloproliferative disorder in a newborn with Down Syndrome treated with rasburicase for the risk of development of tumor lysis syndrome A case report Athanasios Tragiannidis Zoe Dorothea Pana Theodotis Papageorgiou Emmanuel Hatzipantelis Maria Hatzistilianou and Fani Athanassiadou Abstract Introduction Transient myeloproliferative disorder is a hematologic abnormality characterized by an uncontrolled proliferation of myeloblasts in peripheral blood and bone marrow that primarily affects newborns and babies with Down syndrome. Tumor lysis syndrome is rarely associated with transient myeloproliferative disorder. Case presentation Transient myeloproliferative disorder was diagnosed in a seven-day-old baby girl with Down syndrome who was referred to our department due to hyperleukocytosis. Our patient developed tumor lysis syndrome successfully treated with rasburicase as a complication of transient myeloproliferative disorder resulting from rapid degradation of myeloid blasts after initiation of effective chemotherapy. Conclusions Tumor lysis syndrome is rarely reported as a complication of transient myeloproliferative disorder. To the best of our knowledge this is the first case of a newborn with Down syndrome and transient myeloproliferative disorder treated with rasburicase for developing tumor lysis syndrome. Introduction Transient myeloproliferative disorder TMD of Down syndrome DS also known as transient abnormal mye-lopoiesis characteristically manifests in the first few days of life with numerous circulating blast cells exceeding the number of blast cells in the bone marrow and with spontaneous or no resolution within a few weeks 1-3 . Occasionally however TMD has preceded acute megakaryoblastic leukemia AML-M7 after a period of remission lasting several months to years 4-6 . Tumor .

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