TAILIEUCHUNG - Air pollution exposure estimation using dispersion modelling and continuous monitoring data in a prospective birth cohort study in the Netherlands

Accordingly, for the purpose of impact assessment, it was decided not to use response functions from daily mortality time-series studies to estimate the excess annual mortality but the change in the long-term mortality rates associated with ambient air pollution. 5 Contrary to the exposure function which is assumed to be the same for all countries, the health outcome frequency (frequency with which a health outcome appears in the population for a defined time span) may differ across countries. These differences may result from a different age structure or from other factors (. drinking and eating habits, different health care systems in the three countries, etc.). Therefore. | Van den Hooven et al. Environmental Health 2012 11 9 http content 11 1 9 ENVIRONMENTAL HEALTH METHODOLOGY Open Access Air pollution exposure estimation using dispersion modelling and continuous monitoring data in a prospective birth cohort study in the Netherlands 123 2 2 2 2 Edith H Van den Hooven 1 Frank H Pierik Sjoerd W Van Ratingen Peter YJ Zandveld Ernst W Meijer Albert Hofman3 Henk ME Miedema2 Vincent WV Jaddoe1 3 4 and Yvonne De Kluizenaar2 Abstract Previous studies suggest that pregnant women and children are particularly vulnerable to the adverse effects of air pollution. A prospective cohort study in pregnant women and their children enables identification of the specific effects and critical periods. This paper describes the design of air pollution exposure assessment for participants of the Generation R Study a population-based prospective cohort study from early pregnancy onwards in 9778 women in the Netherlands. Individual exposures to PM10 and NO2 levels at the home address were estimated for mothers and children using a combination of advanced dispersion modelling and continuous monitoring data taking into account the spatial and temporal variation in air pollution concentrations. Full residential history was considered. We observed substantial spatial and temporal variation in air pollution exposure levels. The Generation R Study provides unique possibilities to examine effects of short- and long-term air pollution exposure on various maternal and childhood outcomes and to identify potential critical windows of exposure. Keywords Air pollution Dispersion modelling Particulate matter Nitrogen dioxide Cohort study Pregnant women Prenatal development Child health Background Air pollution exposure has been associated with several adverse health effects such as cardiovascular disease respiratory disease and total mortality 1-4 . Certain subgroups of the population including pregnant women and their unborn children have been suggested

• Môi trường
• pessimistic investors
• optimistic beliefs
• Applied Mathematics
• Effect
• Guess Function
• Continuation Method