TAILIEUCHUNG - Báo cáo khoa học: The sigma factors of Mycobacterium tuberculosis: regulation of the regulators

One of the important determinants of virulence of Mycobacterium tuberculosis is adaptation to adverse conditions encountered in the host cells. The ability of Mycobacteriumto successfully adapt to stress condi-tions is brought about by the expression of specific regulons effected by a repertoire of rfactors. | ỊFEBS Journal REVIEW ARTICLE The sigma factors of Mycobacterium tuberculosis regulation of the regulators Preeti Sachdeva1 Richa Misra1 Anil K. Tyagi2 and Yogendra Singh1 1 Institute of Genomics and Integrative Biology CSIR MallRoad Near Jubilee Hall Delhi India 2 Department of Biochemistry University of Delhi South Campus New Delhi India Keywords Mycobacterium post-translational regulation sigma factor tuberculosis One of the important determinants of virulence of Mycobacterium tuberculosis is adaptation to adverse conditions encountered in the host cells. The ability of Mycobacterium to successfully adapt to stress condi- Correspondence Y. Singh Institute of Genomics and Integrative Biology MallRoad Delhi 110007 India Fax 11 2766 7471 Tel 11 2766 6156 E-mail ysingh@ tions is brought about by the expression of specific regulons effected by a repertoire of o factors. The induction and availability of o factors in response to specific stimuli is governed by a complex regulatory network comprising a number of proteins including o factors themselves. A serinethreonine protein kinase-mediated signaling pathway adds another dimension to the mycobacterial o factor regulatory network. This review highlights the recent advances in understanding mycobacterial o factors their Received 8 September 2009 revised 27 October 2009 accepted 4 November 2009 regulation and contribution to bacterial pathogenesis. doi Introduction The causative agent of tuberculosis TB the intracellular bacterial pathogen Mycobacterium tuberculosis latently infects about one-third of the world s population and claims one life every 15 s. Although the World Health Organization-recommended treatment strategy for the detection and cure of TB the Directly Observed Treatment Short-course DOTS has reduced the burden of TB to a great extent the incidence of TB has shown an increase in recent years as a result of the emergence of drug-resistant TB and co-infection .

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