TAILIEUCHUNG - báo cáo khoa học: "Targeted therapy in lymphoma"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài:Targeted therapy in lymphoma | Johnston et al. Journal of Hematology Oncology 2010 3 45 http content 3 1 45 JOURNAL OF HEMATOLOGY ONCOLOGY REVIEW Open Access Targeted therapy in lymphoma Patrick B Johnston1 RuiRong Yuan2 Franco Cavalli3 Thomas E Witzig1 Abstract Discovery of new treatments for lymphoma that prolong survival and are less toxic than currently available agents represents an urgent unmet need. We now have a better understanding of the molecular pathogenesis of lymphoma such as aberrant signal transduction pathways which have led to the discovery and development of targeted therapeutics. The ubiquitin-proteasome and the Akt mammalian target of rapamycin mTOR pathways are examples of pathological mechanisms that are being targeted in drug development efforts. Bortezomib a small molecule protease inhibitor and the mTOR inhibitors temsirolimus everolimus and ridaforolimus are some of the targeted therapies currently being studied in the treatment of aggressive relapsed refractory lymphoma. This review will discuss the rationale for and summarize the reported findings of initial and ongoing investigations of mTOR inhibitors and other small molecule targeted therapies in the treatment of lymphoma. Introduction Despite remarkable advances in diagnosis and treatment lymphoma continues to rank as a leading cause of cancer-related mortality. Recent cancer statistics for the United States project non-Hodgkin lymphoma NHL to be the sixth most commonly diagnosed cancer in 2010 in both men and women and the eighth and sixth leading cause of cancer-related death in men and women respectively 1 . Based on data from national cancer registries 65 540 new cases of NHL and 20 210 deaths from NHL are estimated to occur in 2010. In contrast Hodgkin lymphoma HL is less common 8 490 estimated new cases in 2010 and is associated with fewer deaths 1 320 estimated deaths in 2010 1 . In the European Union reported NHL estimates for the year 2006 were even higher with 72 800 new cases and 33 .

TÀI LIỆU LIÊN QUAN
Đã phát hiện trình chặn quảng cáo AdBlock
Trang web này phụ thuộc vào doanh thu từ số lần hiển thị quảng cáo để tồn tại. Vui lòng tắt trình chặn quảng cáo của bạn hoặc tạm dừng tính năng chặn quảng cáo cho trang web này.