TAILIEUCHUNG - Apoptosis in Neurobiology: Concepts and Methods

Apoptosis in the developing nervous system results in naturally occurring cell death (NOCD), a necessary and desirable process. NOCD effectively eliminates neurons that have made faulty synapses or have not reached appropriate targets. 1 In the rest of the organism, apoptosis is essential for organogenesis, sculpts digits and extremities, and plays a role in determining polarity of structures by contributing to directional growth of cell populations. 2 Failure of carefully orchestrated and effective apoptosis in the developing fetus can have serious and long-lasting effects in the adult. Congenital brain malformations such as heterotopias, schizencephaly, myelomeningocoele, and many others probably represent poorly designed and/or incomplete apoptosis | APOPTOSIS in Yum. lUmun Apoptosis in Neurobiology Concepts and Methods Edited by Yusuf A Hannun and Rose-Mary Boustany 1999 by CRC Press LLC Library of Congress Cataloging-in-Publication Data Catalog record is available from the Libray of Congress This book contains information obtained from authentic and highly regarded sources. Reprinted material is quoted with permission and sources are indicated. A wide variety of references are listed. Reasonable efforts have been made to publish reliable data and information but the author and the publisher cannot assume responsibility for the validity of all materials or for the consequences of their use. Neither this book nor any part may be reproduced or transmitted in any form or by any means electronic or mechanical including photocopying microfilming and recording or by any information storage or retrieval system without prior permission in writing from the publisher. All rights reserved. Authorization to photocopy items for internal or personal use or the personal or internal use of specific clients may be granted by CRC Press LLC provided that .50 per page photocopied is paid directly to Copyright Clearance Center 27 Congress Street Salem MA 01970 USA. The fee code for users of the Transactional Reporting Service is ISBN 0-8493-3352-0 99 .50. The fee is subject to change without notice. For organizations that have been granted a photocopy license by the CCC a separate system of payment has been arranged. The consent of CRC Press LLC does not extend to copying for general distribution for promotion for creating new works or for resale. Specific permission must be obtained in writing from CRC Press LLC for such copying. Direct all inquiries to CRC Press LLC 2000 Corporate Blvd. . Boca Raton Florida 33431. 1999 by CRC Press LLC No claim to original . Government works International Standard Book Number 0-8493-3352-0 Printed in the United States of America 1 2 3 4 5 6 78 9 0 Printed on acid-free paper 1999 by .

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