TAILIEUCHUNG - Báo cáo y học: "Revisiting the pathogenesis of podagra: why does gout target the foo"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Revisiting the pathogenesis of podagra: why does gout target the foot? | JOURNAL OF FOOT AND ANKLE RESEARCH Revisiting the pathogenesis of podagra why does gout target the foot Roddy Roddy Journal of Foot and Ankle Research 2011 4 13 http content 4 1 13 13 May 2011 BioMed Central Roddy Journal of Foot and Ankle Research 2011 4 13 http content 4 1 13 JOURNAL OF FOOT AND ANKLE RESEARCH REVIEW Open Access Revisiting the pathogenesis of podagra why does gout target the foot Edward Roddy Abstract This invited paper provides a summary of a keynote lecture delivered at the 2011 Australasian Podiatry Conference. Gout is the most prevalent inflammatory arthropathy. It displays a striking predilection to affect the first metatarsophalangeal joint as well as joints within the mid-foot and ankle. A number of factors are known to reduce urate solubility and enhance nucleation of monosodium urate crystals including decreased temperature lower pH and physical shock all of which may be particularly relevant to crystal deposition in the foot. An association has also been proposed between monosodium urate crystal deposition and osteoarthritis which also targets the first metatarsophalangeal joint. Cadaveric clinical and radiographic studies indicate that monosodium urate crystals more readily deposit in osteoarthritic cartilage. Transient intra-articular hyperuricaemia and precipitation of monosodium urate crystals is thought to follow overnight resolution of synovial effusion within the osteoarthritic first metatarsophalangeal joint. The proclivity of gout for the first metatarsophalangeal joint is likely to be multi-factorial in origin arising from the unique combination of the susceptibility of the joint to osteoarthritis and other determinants of urate solubility and crystal nucleation such as temperature and minor physical trauma which are particularly relevant to the foot. Background Gout is a true crystal deposition disease in which all clinical manifestations are considered to be directly attributable .

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