TAILIEUCHUNG - Báo cáo y học: "Fragmentation of decorin, biglycan, lumican and keratocan is elevated in degenerate human meniscus, knee and hip articular cartilages compared with age-matched macroscopically normal and control tissues"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Fragmentation of decorin, biglycan, lumican and keratocan is elevated in degenerate human meniscus, knee and hip articular cartilages compared with age-matched macroscopically normal and control tissues. | Available online http content 10 4 R79 Research article Fragmentation of decorin biglycan lumican and keratocan is elevated in degenerate human meniscus knee and hip articular cartilages compared with age-matched macroscopically normal and control tissues James Melrose1 Emily S Fuller1 Peter J Roughley2 Margaret M Smith1 Briedgeen Kerr3 Clare E Hughes3 Bruce Caterson3 and Christopher B Little1 1Raymond Purves Research Laboratory Institute of Bone Joint Research Kolling Institute of Medical Research University of Sydney Royal North Shore Hospital Reserve Road St. Leonards NSW 2065 Australia 2Genetics Unit 1529 Cedar Rm 338 Shriners Hospital for Children McGill University Montreal Quebec H3G 1A6 Canada 3School of Molecular and Medical Biosciences PO Box 911 University of Cardiff Cardiff CF1 3US UK Corresponding author James Melrose jmelrose@ Received 23 Apr 2008 Revisions requested 10 Jun 2008 Revisions received 18 Jun 2008 Accepted 14 Jul 2008 Published 1 4 Jul 2008 Arthritis Research Therapy 2008 10 R79 doi ar2453 This article is online at http content 10 4 R79 2008 Melrose et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction The small leucine-rich proteoglycans SLRPs modulate tissue organization cellular proliferation matrix adhesion growth factor and cytokine responses and sterically protect the surface of collagen type I and II fibrils from proteolysis. Catabolism of SLRPs has important consequences for the integrity of articular cartilage and meniscus by interfering with their tissue homeostatic functions. Methods SLRPs were dissociatively extracted from articular cartilage from total knee and hip replacements .

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