TAILIEUCHUNG - Báo cáo y học: " Caspase-mediated cleavage of the exosome subunit PM/Scl-75 during apoptosis."

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Caspase-mediated cleavage of the exosome subunit PM/Scl-75 during apoptosis. | Available online http content 9 1 R12 Research article Caspase-mediated cleavage of the exosome subunit PM Scl-75 during apoptosis Geurt Schilders1 Reinout Raijmakers1 Kelen CR Malmegrim1 2 Lieselotte Vande Walle3 Xavier Saelens3 Wilma Vree Egberts1 Walther J van Venrooij1 Peter Vandenabeele3 and Ger JM Pruijn1 Department of Biomolecular Chemistry Nijmegen Center for Molecular Life Sciences Institute for Molecules and Materials Radboud University Nijmegen Geert Grooteplein 26-28 Nijmegen 6525 GA The Netherlands 2Center for Cell-Based Therapy Faculty of Medicine of Ribeirão Preto University of São Paulo Ribeirão Preto São Paulo 14049-900 Brazil department of Molecular Biomedical Research Flanders Interuniversity Institute for Biotechnology Ghent University Technologiepark 927 Ghent B-9052 Belgium Corresponding author Ger JM Pruijn Received 8 Nov 2006 Revisions requested 18 Dec 2006 Revisions received 4 Jan 2007 Accepted 5 Feb 2007 Published 5 Feb 2007 Arthritis Research Therapy 2007 9 R12 doi ar2119 This article is online at http content 9 1 R12 2007 Schilders et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Recent studies have implicated the dying cell as a potential reservoir of modified autoantigens that might initiate and drive systemic autoimmunity in susceptible hosts. A number of subunits of the exosome a complex of 3 5 exoribonucleases that functions in a variety of cellular processes are recognized by the so-called anti-PM Scl autoantibodies found predominantly in patients suffering from an overlap syndrome of myositis and scleroderma. Here we show that one of these subunits PM Scl-75 is cleaved during apoptosis. PM

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