TAILIEUCHUNG - Báo cáo khoa học: "Gemcitabine/cisplatin versus 5-fluorouracil/ mitomycin C chemoradiotherapy in locally advanced pancreatic cancer: a retrospective analysis of 93 patients"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Gemcitabine/cisplatin versus 5-fluorouracil/ mitomycin C chemoradiotherapy in locally advanced pancreatic cancer: a retrospective analysis of 93 patients. | Brunner et al. Radiation Oncology 2011 6 88 http content 6 1 88 RADIATION ONCOLOGY RESEARCH Open Access Gemcitabine cisplatin versus 5-fluorouracil mitomycin C chemoradiotherapy in locally advanced pancreatic cancer a retrospective analysis of 93 patients Thomas B Brunner1 2 Rolf Sauer1 and Rainer Fietkau1 Abstract Background Despite of a growing number of gemcitabine based chemoradiotherapy studies in locally advanced pancreatic cancer LAPC 5-fluorouracil based regimens are still regarded to be standard and the debate of superiority between the two drugs is going on. The aim of this retrospective analysis was to evaluate the effect of two concurrent chemoradiotherapy regimens using 5-fluorouracil or gemcitabine to compare their effect and tolerance. Methods We have performed a single centre retrospective analysis of 93 patients treated with conventionally fractionated radiotherapy of Gray using either concurrent 5-fluorouracil 1 g m2 on days 1-5 and 29-33 of radiotherapy and 10 mg m2 of mitomycin C on day 1 29 of radiotherapy FM group 35 patients versus gemcitabine 300 mg m2 and cisplatin 30 mg m2 on days 1 8 22 and 29 GC group 58 patients . Primary endpoint was the median overall survival OS rate. Results The median OS rate was months in the GC group and months in the FM group. The 1-year OS rate was 53 versus 40 respectively p . GC led to more grade 3 leukocytopenia and thrombocytopenia than FM but not to more grade 4 myelosuppression. Thrombocytopenia was the most frequently observed grade 4 toxicity in both groups 11 after FM versus 12 after GC . No grade 3 4 febrile neutropenia was observed. Grade 3 nausea was more common in the FM group 20 versus 9 and grade 4 nausea was observed in one patient per group only. Conclusions GC was superior to FM for overall survival and both regimens were similar in terms of tolerance. We conclude that GC leads to encouraging results and that the use of FM for chemoradiotherapy in LAPC .

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