TAILIEUCHUNG - Báo cáo khoa học: "The initial experience of electronic brachytherapy for the treatment of non-melanoma skin cancer"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: The initial experience of electronic brachytherapy for the treatment of non-melanoma skin cancer. | Bhatnagar and Loper Radiation Oncology 2010 5 87 http content 5 1 87 RADIATION ONCOLOGY RESEARCH Open Access The initial experience of electronic brachytherapy for the treatment of non-melanoma skin cancer Ajay Bhatnagar1 2 Alphonse Loper2 Abstract Background Millions of people are diagnosed with non-melanoma skin cancers NMSC worldwide each year. While surgical approaches are the standard treatment some patients are appropriate candidates for radiation therapy for NMSC. High dose rate HDR brachytherapy using surface applicators has shown efficacy in the treatment of NMSC and shortens the radiation treatment schedule by using a condensed hypofractionated approach. An electronic brachytherapy EBT system permits treatment of NMSC without the use of a radioactive isotope. Methods Data were collected retrospectively from patients treated from July 2009 through March 2010. Pre-treatment biopsy was performed to confirm a malignant cutaneous diagnosis. A CT scan was performed to assess lesion depth for treatment planning and an appropriate size of surface applicator was selected to provide an acceptable margin. An HDR EBT system delivered a dose of Gy in eight fractions twice weekly with 48 hours between fractions prescribed to a depth of 3-7 mm. Treatment feasibility acute safety efficacy outcomes and cosmetic results were assessed. Results Thirty-seven patients mean age years with 44 cutaneous malignancies were treated. Of 44 lesions treated 39 89 were T1 1 2 Tis 1 2 T2 and 3 7 lesions were recurrent. Lesion locations included the nose for 16 lesions ear 5 11 scalp 5 11 face 14 32 and an extremity for 4 9 . Median follow-up was months. No severe toxicities occurred. Cosmesis ratings were good to excellent for 100 of the lesions at follow-up. Conclusions The early outcomes of EBT for the treatment of NMSC appear to show acceptable acute safety and favorable cosmetic outcomes. Using a hypofractionated approach EBT provides a .

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