TAILIEUCHUNG - Báo cáo khoa học: "Simultaneous in-field boost for patients with 1 to 4 brain metastasis/es treated with volumetric modulated arc therapy: a prospective study on quality-of-life"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Simultaneous in-field boost for patients with 1 to 4 brain metastasis/es treated with volumetric modulated arc therapy: a prospective study on quality-of-life. | Weber et al. Radiation Oncology 2011 6 79 http content 6 1 79 RADIATION ONCOLOGY RESEARCH Open Access Simultaneous in-field boost for patients with 1 to 4 brain metastasis es treated with volumetric modulated arc therapy a prospective study on quality-of-life 1 1 1 Damien C Weber Francesca Caparrotti Mohamed Laouiti and Karim Malek Abstract Purpose To assess treatment toxicity and patients survival quality of life QoL after volumetric modulated arc therapy VMAT with simultaneous in-field boost SIB for cancer patients with 1 - 4 brain metastases BM treated with or without surgery. Methods and Materials Between March and December 2010 29 BM patients total volume BM 40 cm3 aged 80 years KPS 70 RPA III were included in this prospective trial. Whole brain VMAT 30 Gy and a SIB to the BM 40 Gy was delivered in 10 fraction. Mean age was years. Fifteen underwent surgery. KPS and MMSE were prospectively assessed. A self-assessed questionnaire was used to assess the QoL EORTC QLQ-C30 with -BN20 module . Results As of April 2011 and after a mean FU of months 14 patients died. The 6-month overall survival was . Alopecia was only observed in 9 31 patients. In 3-month survivors KPS was significantly p decreased. MMSE score remained however stable p . Overall QoL did decrease after VMAT. The mean QLQ-C30 global health status p and emotional functional p scores were decreased low QoL . Physical p and role functioning score p were significantly worse and rapidly decreased during treatment. The majority of BN20 domains and single items worsened 3 months after VMAT except headaches p and bladder control p which improved. Conclusions The delivery of 40 Gy in 10 fractions to 1 - 4 BM using VMAT was achieved with no significant toxicity. QoL performance status but not MMSE was however compromised 3 months after treatment in this selected cohort of BM patients. Introduction Brain metastases BMs

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