TAILIEUCHUNG - Báo cáo khoa học: "Breathing adapted radiotherapy: a 4D gating software for lung cancer"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Breathing adapted radiotherapy: a 4D gating software for lung cancer. | Peguret et al. Radiation Oncology 2011 6 78 http content 6 1 78 RADIATION ONCOLOGY METHODOLOGY Open Access Breathing adapted radiotherapy a 4D gating software for lung cancer 1 1 1 332 Nicolas Peguret Jacqueline Vock Vincent Vinh-Hung Pascal Fenoglietto David Azria Habib Zaidi Michael Wissmeyer2 Osman Ratib2 and Raymond Miralbell1 Abstract Purpose Physiological respiratory motion of tumors growing in the lung can be corrected with respiratory gating when treated with radiotherapy RT . The optimal respiratory phase for beam-on may be assessed with a respiratory phase optimizer RPO a 4D image processing software developed with this purpose. Methods and Materials Fourteen patients with lung cancer were included in the study. Every patient underwent a 4D-CT providing ten datasets often phases of the respiratory cycle 0-100 of the cycle . We defined two morphological parameters for comparison of 4D-CT images in different respiratory phases tumor-volume to lungvolume ratio and tumor-to-spinal cord distance. The RPO automatized the calculations 200 per patient of these parameters for each phase of the respiratory cycle allowing to determine the optimal interval for RT. Results Lower lobe lung tumors not attached to the diaphragm presented with the largest motion with breathing. Maximum inspiration was considered the optimal phase for treatment in 4 patients . In 7 patients 50 however the RPO showed a most favorable volumetric and spatial configuration in phases other than maximum inspiration. In 2 cases the RPO showed no benefit from gating. This tool was not conclusive in only one case. Conclusions The RPO software presented in this study can help to determine the optimal respiratory phase for gated RT based on a few simple morphological parameters. Easy to apply in daily routine it may be a useful tool for selecting patients who might benefit from breathing adapted RT. Keywords Lung cancer radiotherapy 4D-CT gating Introduction Lung cancer .

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