TAILIEUCHUNG - Báo cáo y học: "Nurse-like cells reside in the synovial tissue and bone marrow in rheumatoid arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Nurse-like cells reside in the synovial tissue and bone marrow in rheumatoid arthritis. | Available online http content 9 1 201 Review Mesenchymal stromal cells Nurse-like cells reside in the synovial tissue and bone marrow in rheumatoid arthritis Takahiro Ochi1 Hideki Yoshikawa2 Tomoko Toyosaki-Maeda3 and Peter E Lipsky4 1Sagamihara National Hospital Sagamihara Kanagawa Japan 2Department of Orthopaedic Surgery Osaka University Medical School Suita Osaka Japan 3Department of Immunology Shionogi Research Laboratories Shionogi Co. Ltd Osaka Japan 4National Institute of Arthritis and Musculoskeletal and Skin Diseases Bethesda MD 20892 USA Corresponding author Takahiro Ochi t-ochi@ Published 12 February 2007 This article is online at http content 9 1 201 2007 BioMed Central Ltd Arthritis Research Therapy 2007 9 201 doi ar2105 Abstract A major question concerning the immunopathology of rheumatoid arthritis is why the disease is localized to particular joints. A possible explanation could be the presence within the synovium of cells that foster inflammation or easy accessibility of the synovium to migratory disease enhancing cells. Within both the bone marrow and the synovium fibroblastic stromal cells play an important role in supporting the differentiation and survival of normal cells and also contribute to the pathologic processes. Among fibroblastic stromal cells in synovial tissue and bone marrow nurse-like cells are a unique population having the specific capacity to promote pseudoemperipolesis adhesion and holding beneath of lymphocytes and also the ability to promote the growth and function of some populations of lymphocytes and monocytes. Nurse-like cells could therefore contribute to the immunopathogenesis of rheumatoid arthritis and may contribute to the localization of inflammation within specific joints. The present review considers the evidence that supports these possibilities. Introduction Rheumatoid arthritis RA is a chronic autoimmune disease characterized by .

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