TAILIEUCHUNG - Báo cáo y học: "Reactive oxygen species induce expression of vascular endothelial growth factor in chondrocytes and human articular cartilage explants"
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Reactive oxygen species induce expression of vascular endothelial growth factor in chondrocytes and human articular cartilage explants. | Available online http content 8 6 R189 Research article Reactive oxygen species induce expression of vascular endothelial growth factor in chondrocytes and human articular cartilage explants Jakob Fay1 Deike Varoga2 Christoph J Wruck2 Bodo Kurz2 Mary B Goldring3 4 and Thomas Pufe2 Department of Trauma Surgery University Hospital Schleswig-Holstein Campus Kiel Arnold-Heller-Strasse 7 24105 Kiel Germany department of Anatomy Christian-Albrechts-University Kiel Olshausenstrasse 40 24098 Kiel Germany 3Beth Israel Deaconess Medical Center New England Baptist Bone and Joint Institute Harvard Institutes of Medicine HIM-246 4 Blackfan Circle Boston MA 02115-5713 USA _ 4Hospital for Special Surgery Caspary Research Building Room 528 535 E. 70th Street New York NY 10021 USA Corresponding author Thomas Pufe Received 13 Oct 2006 Revisions requested 9 Nov 2006 Revisions received 1 Dec 2006 Accepted 23 Dec 2006 Published 23 Dec 2006 Arthritis Research Therapy 2006 8 R189 doi ar2102 This article is online at http content 8 6 R189 2006 Fay et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Vascular endothelial growth factor VEGF promotes cartilagedegrading pathways and there is evidence for the involvement of reactive oxygen species ROS in cartilage degeneration. However a relationship between ROS and VEGF has not been reported. Here we investigate whether the expression of VEGF is modulated by ROS. Aspirates of synovial fluid from patients with osteoarthritis OA were examined for intra-articular VEGF using ELISA. Immortalized C28 I2 chondrocytes and human knee cartilage explants were exposed to phorbol myristate acetate PMA 020 pg ml .
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