TAILIEUCHUNG - Báo cáo y học: "Diagnostic value of antibodies against a modified citrullinated vimentin in rheumatoid arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Diagnostic value of antibodies against a modified citrullinated vimentin in rheumatoid arthritis. | Available online http content 8 4 R119 Research article Diagnostic value of antibodies against a modified citrullinated vimentin in rheumatoid arthritis Christian Dejaco1 2 Werner Klotz1 Heike Larcher1 Christina Duftner1 Michael Schirmer2 and Manfred Herold1 Clinical Department of Internal Medicine Division of General Internal Medicine Innsbruck Medical University Anichstrasse 35 6020 Innsbruck Austria 2General Hospital of the Elizabethenians Voelkermarkterstrasse 15-19 9020 Klagenfurt Austria Corresponding author Manfred Herold Received 5 May 2006 Revisions requested 31 May 2006 Revisions received 20 Jun 2006 Accepted 7 Jul 2006 Published 19 Jul 2006 Arthritis Research Therapy 2006 8 R119 doi ar2008 This article is online at http content 8 4 R119 2006 Dejaco et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Antibodies directed against citrullinated vimentin are members of the family of autoantibodies reactive with citrullinated proteins and are among the most specific serological markers for the diagnosis of rheumatoid arthritis RA . This study was performed to test the diagnostic value of a newly developed enzyme-linked immunosorbent assay ELISA for the detection of antibodies against a genetically modified citrullinated vimentin anti-MCV in comparison with a second-generation anti-cyclic citrullinated peptides anti-CCP2 ELISA test system. Blinded sera from 631 patients 409 consecutive out-patients and 222 randomly selected stored sera with RA n 164 and non-RA osteoarthritis n 120 polymyalgia rheumatica giant cell arteritis n 80 spondyloarthritis n 36 and other inflammatory rheumatic or non-inflammatory disease n 67 .

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