TAILIEUCHUNG - Báo cáo khoa học: "Bony metastases from breast cancer - a study of foetal antigen 2 as a blood tumour markerl"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Bony metastases from breast cancer - a study of foetal antigen 2 as a blood tumour marker | Cheung et al. World Journal of Surgical Oncology 2010 8 38 http content 8 1 38 WORLD JOURNAL OF SURGICAL ONCOLOGY RESEARCH Open Access Bony metastases from breast cancer - a study of foetal antigen 2 as a blood tumour marker Kwok-Leung Cheung 1 Ray K Iles2 and John FR Robertson1 Abstract Background Foetal antigen 2 FA-2 first isolated in the amniotic fluid was shown to be the circulating form of the aminopropeptide of the alpha 1 chain of procollagen type I. Serum concentrations of FA-2 appeared to be elevated in a number of disorders of bone metabolism. This paper is the first report of its role as a marker of bone metabolism in metastatic breast cancer. Methods Serum FA-2 concentrations were measured by radioimmunoassay in 153 women with different stages of breast cancer and in 34 normal controls. Results Serum FA-2 was significantly elevated in women with bony metastases p . Its levels were not significantly different among women with non-bony metastases with non-metastatic disease as well as among normal controls. Conclusions FA-2 is a promising blood marker of bone metabolism. Further studies to delineate its role in the diagnosis and management of bony metastases from breast cancer are required. Background Foetal antigen 2 FA-2 was first isolated in the amniotic fluid 1 and subsequent structural characterisation showed that it was the circulating form of the aminopropeptide of the alpha 1 chain of procollagen type I 2 . As will be discussed later serum concentrations of FA-2 appeared to be elevated in a number of disorders with altered bone metabolism. The bone is the commonest site of involvement in metastatic breast cancer. Bone metabolism including formation and resorption is influenced by the disease process by anti-cancer therapies cytotoxic or endocrine therapy and by the recently popularised use of bisphosphonates. A circulating marker which can better reflect the process of bone metabolism is needed in the management of women with .

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