TAILIEUCHUNG - Báo cáo khoa học: Nuclear receptors in the mosquito Aedes aegypti Annotation, hormonal regulation and expression profiling

Alterations resulting in enhanced epidermal growth factor receptor (EGFR) expression or function have been documented in a variety of tumors. Therefore, EGFR-tyrosine kinase is a promising therapeutic target. Althoughin vitro andin vivo studies have shown the anti-tumor activity of EGFR-tyrosine kinase inhibitors against various tumor types, little is known about the mechanism by which such inhibitors effect their anti-tumor action. | Nuclear receptors in the mosquito Aedes aegypti Annotation hormonal regulation and expression profiling Josefa Cruz Douglas H. Sieglaff f Peter Arensburger Peter W. Atkinson and Alexander S. Raikhel Department of Entomology and the Institute for Integrative Genome Biology University of California Riverside CA USA Keywords ecdysone receptor 20-hydroxyecdysone nuclear receptor reproduction yolk protein Correspondence A. S. Raikhel Department of Entomology University of California Riverside Watkins Drive CA 92521 USA Fax 1 951 827 2140 Tel 1 951 827 2146 E-mail araikhel@ fPresent address Institute for Genomics and Bioinformatics Microbiology and Molecular Genetics University of California Irvine CA USA These authors contributed equally to this work Received 29 May 2008 revised 11 December 2008 accepted 16 December 2008 doi In anautogenous mosquitoes egg development requires blood feeding and as a consequence mosquitoes act as vectors of numerous devastating diseases of humans and domestic animals. Understanding the molecular mechanisms regulating mosquito egg development may contribute significantly to the development of novel vector-control strategies. Previous studies have shown that in the yellow fever mosquito Aedes aegypti nuclear receptors NRs play a key role in the endocrine regulation of reproduction. However many mosquito NRs remain uncharacterized some of which may play an important role in mosquito reproduction. Publication of the genome of A. aegypti allowed us to identify all NRs in this mosquito based on their phylogenetic relatedness to those within Insecta. We have determined that there are 20 putative A. aegypti NRs some of which are predicted to have different isoforms. As the first step toward analysis of this gene family we have established their expression within the two main reproductive tissues of adult female mosquitoes fat body and ovary. All NR transcripts are present in both tissues most displaying .

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