TAILIEUCHUNG - Báo cáo y học: " Phosphatidylserine receptor and apoptosis: consequences of a non-ingested meal"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Phosphatidylserine receptor and apoptosis: consequences of a non-ingested meal. | Available online http content 6 4 147 Commentary Phosphatidylserine receptor and apoptosis consequences of a non-ingested meal Marina Botto Rheumatology Section Eric Bywaters Centre Faculty of Medicine Imperial College London UK Corresponding author Marina Botto e-mail Received 8 Mar 2004 Revisions requested 5 Apr 2004 Revisions received 19 Apr 2004 Accepted 28 Apr 2004 Published 4 Jun 2004 Arthritis Res Ther 2004 6 147-150 DOI ar1191 2004 BioMed Central Ltd Abstract Apoptosis a physiological process of controlled cell death is essential during embryonic development and for the maintenance of tissue homeostasis. In recent years the view has emerged that dying cells can provide specific signals that enable recruitment and recognition by phagocytes. Exposure of phosphatidylserine the best characterized of such signals allows safe clearance of apoptotic waste without induction of inflammation. Here I re-examine some of the arguments that underpin the importance of these clearance mechanisms in light of recent observations from an animal model that lacks the receptor specific for phosphatidylserine. Keywords apoptosis autoimmunity inflammation phagocytosis Introduction Apoptosis is an active process of cell suicide that leads to ordered destruction of the cells and their safe disposal by professional macrophages and immature dendritic cells and nonprofessional such as fibroblasts and epithelial cells phagocytes 1 . The removal of apoptotic cells is the final step and perhaps the ultimate objective of the apoptotic programme. When apoptosis was initially described by Kerr and coworkers 2 the phenomenon of programmed cell death was greeted with a striking lack of interest. It has now become apparent that the process is ubiquitous and plays a key role in many fundamental biological events including embryonic development normal tissue homeostasis development of the immune system and resolution of inflammation. In .

TỪ KHÓA LIÊN QUAN
Đã phát hiện trình chặn quảng cáo AdBlock
Trang web này phụ thuộc vào doanh thu từ số lần hiển thị quảng cáo để tồn tại. Vui lòng tắt trình chặn quảng cáo của bạn hoặc tạm dừng tính năng chặn quảng cáo cho trang web này.