TAILIEUCHUNG - Báo cáo y học: " Ageing, autoimmunity and arthritis: Senescence of the B cell compartment — implications for humoral immunity"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Ageing, autoimmunity and arthritis: Senescence of the B cell compartment — implications for humoral immunity. | Available online http content 6 4 131 Review Ageing autoimmunity and arthritis Senescence of the B cell compartment - implications for humoral immunity Sara A Johnson and John C Cambier Integrated Department of Immunology University of Colorado Health Sciences Center and National Jewish Medical and Research Center Denver Colorado USA Corresponding author John C Cambier e-mail cambierj@ Received 1 Dec 2003 Revisions requested 2 Feb 2004 Revisions received 4 Mar 2004 Accepted 30 Mar 2004 Published 10 May 2004 Arthritis Res Ther 2004 6 131-139 DOI ar1180 2004 BioMed Central Ltd Abstract Immunoseneseenee is associated with a decline in both T and B lymphocyte function. Although aged individuals have normal numbers of B cells in the periphery and are capable of mounting robust humoral responses the antibodies produced are generally of lower affinity and are less protective than those produced by young animals. Here we review multiple studies that address the mechanisms that contribute to this decline. Taken together these studies suggest that age-associated loss of the ability to generate protective humoral immunity results in part from reduced B lymphopoiesis. As the output of new naive B cells declines homeostatic pressures presumably force the filling of the peripheral B cell pool by long-lived antigen-experienced cells. Because the antibody repertoire of these cells is restricted by previous antigenic experience they make poor quality responses to new immunologic insults. Keywords aging B cells homeostasis immunosenescence lymphopoiesis Introduction During the past decade the number of laboratories investigating immune senescence has increased dramatically rapidly advancing our understanding of how the immune systems of higher organisms change with age. Historically aging has been thought of as a state of immune deficiency. Elderly individuals present with increased susceptibility to and severity of infectious diseases and .

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