TAILIEUCHUNG - Báo cáo y học: "Hypoxia: not merely a regulator of angiogenesis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Hypoxia: not merely a regulator of angiogenesis? | Available online http content 6 2 75 Viewpoint Hypoxia not merely a regulator of angiogenesis Ewa Paleolog Kennedy Institute of Rheumatology Division of Surgery Anaesthetics and Intensive Care Faculty of Medicine Imperial College London UK Corresponding author Ewa Paleolog e-mail Received 6 Feb 2004 Accepted 12 Feb 2004 Published 8 Mar 2004 Arthritis Res Ther 2004 6 75-77 DOI ar1160 2004 BioMed Central Ltd Print ISSN 1478-6354 Online ISSN 1478-6362 Introduction Maintaining oxygen homeostasis is of vital importance for the survival and development of mammalian cells. Hypoxia below-normal levels of oxygen in air blood and tissue can potentially lead to cellular dysfunction and ultimately cell death and is a feature of many pathological conditions. Understanding how reduced oxygen levels may contribute to or even promote disease is a significant facet of developing new therapeutic options. A recent study by Cramer et al. gives a fresh insight into these mechanisms and raises questions over whether hypoxia is more than just a regulator of angiogenesis 1 . How do cells respond to changes in oxygen concentration The way in which cells sense and respond to changes in oxygen concentration in their environment has attracted considerable interest. An important and well-characterised master regulator of the adaptive response to alterations in oxygen tension is hypoxia-inducible factor HIF a transcriptional complex containing two a and p members of the basic-helix-loop-helix PAS period-aryl hydrocarbon nuclear receptor translocator-single minded family. Several HIF-a isoforms exist including HIF-1a and HIF-2a. HIF molecules bind specifically to hypoxia-responsive elements in the promoter or enhancer regions of various genes which include erythropoietin vascular endothelial growth factor VEGF glycolytic enzymes and genes involved in iron metabolism 2 . Oxygen levels regulate HIF primarily through a mechanism involving .

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